Colloidal gold and various derivatives have long been among the most widely used labels for antigens in biological electron microscopy. Colloidal gold particles can be attached to many traditional biological probes such as antibodies, lectins, superantigens, glycans, nucleic acids, and receptors.
Functionalized gold nanoparticles with controlled geometrical and optical properties are the subject of intensive studies and biomedical applications, including genomics, biosensorics, immunoassays, clinical chemistry, laser phototherapy of cancer cells and tumors, the targeted delivery of drugs, DNA and antigens, optical bioimaging and the monitoring of cells and tissues with the use of state-of-the-art detection systems.
Also colloidal gold is widely applied in Medical Diagonosis.
Immunological testing is based on the specific biological recognition mechanism of the antigen-antibody reaction. Colloidal gold technology is the most representative immunochromatographic detection method. It combines antigen-antibody immune response with colloidal gold labeling technology for qualitative or quantitative detection of antigen and antibody content, and the test results are generally obtained in 5-10 minutes. The detectable indicators of the colloidal gold immunochromatographic method include hepatitis B surface antigen (HBsAg), human chorionic gonadotropin (human chorionic gonadotropin, HCG, early pregnancy test), anti-double-stranded DNA antibody, etc. The colloidal gold method uses lateral flow assay technology to centralize sample pre-processing, sample addition, reagent mixing and other operations on a single chip, and has a closed environment required for in vitro diagnostic testing. It is simple, convenient, and inexpensive. It is the most commonly used POCT method.
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