DelveInsight’s “Post-Bariatric Hypoglycemia Market Insights, Epidemiology, and Market Forecast 2032” report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the Post-Bariatric Hypoglycemia market size, share, trends, and growth opportunities in the seven major markets (7MM) (i.e., the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom and Japan).
The report covers emerging Post-Bariatric Hypoglycemia drugs, current treatment practices, market share of individual therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current Post-Bariatric Hypoglycemia treatment practice/algorithm, key drivers & barriers impacting the market growth, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.
Post-Bariatric Hypoglycemia: An Overview
Bariatric surgery, or weight loss surgery, is a group of surgical procedures designed to help individuals with severe obesity achieve significant and sustained weight loss. These surgeries are typically recommended for individuals unsuccessful in achieving weight loss through nonsurgical methods, such as diet and exercise, and who have obesity-related health conditions.
Post-Bariatric hypoglycemia is the development of hypoglycemia (low blood sugar) following bariatric surgery, such as gastric bypass or sleeve gastrectomy. It typically occurs within a few years after surgery. Several risk factors contribute to Post-Bariatric hypoglycemia, including rapid weight loss, altered gastrointestinal anatomy, increased insulin sensitivity, hyperinsulinemia, and reactive hypoglycemia.
The pathophysiology of Post-Bariatric hypoglycemia is complex and involves several interrelated mechanisms. It is believed to result from alterations in the normal hormonal and metabolic response to food intake following bariatric surgery.
The management of Post-Bariatric hypoglycemia involves dietary modifications, such as consuming small and frequent meals, avoiding high-glycemic index foods, and restricting simple sugars. Medications, including acarbose, diazoxide, or glucagon-like peptide-1 (GLP-1) receptor agonists, may be prescribed to help control blood sugar levels. In severe cases, surgical interventions, such as partial or complete reversal of the bariatric surgery, may be considered.
Few therapies are being investigated for the treatment of Post-Bariatric hypoglycemia. Some key players involved in the development are Vogenx (mizagliflozin) and Eiger BioPharmaceuticals (Avexitide).
Post-Bariatric Hypoglycemia Market Key Facts
In 2022, the United States accounted for the largest market size among the 7MM countries, making ~89% of the total market size of the 7MM.
Among the 7MM countries, Spain had the market size in 2022, accounting for ~1% of the market size in the 7MM region.
In EU4 and the UK region, France accounted for the largest market size, making up ~6% of the total market size of the EU4 region.
In 2022, the total Post-Bariatric hypoglycemia (PBH) cases in the United States were ~82,000, projected to increase during the forecast period (2023–2032).
The total Post-Bariatric hypoglycemia (PBH) cases in EU4 and the UK were ~21,000 in 2022. The cases will increase during the forecast period (2023–2032).
The total number of Post-Bariatric hypoglycemia (PBH) cases in Japan was ~200 in 2022.
Various key players are leading the treatment landscape of Post-Bariatric hypoglycemia, such as Vogenx and Eiger Biopharmaceuticals.
The market outlook section of the report helps to build a detailed comprehension of the historical, current, and forecasted market size by analyzing the impact of current and emerging Post-Bariatric Hypoglycemia pipeline therapies. It also thoroughly assesses the Post-Bariatric Hypoglycemia market drivers & barriers, unmet needs, and emerging technologies set to impact the market dynamics.
The report gives complete details of the market trend for each marketed Post-Bariatric Hypoglycemia drug and mid & late-stage pipeline therapies by evaluating their impact based on the annual cost of therapy, their Mechanism of Action (MOA), Route of Administration (ROA), molecule types, competition with other therapies, brand value, and their impact on the market.
Post-Bariatric Hypoglycemia Epidemiology Assessment
The epidemiology section provides insights into the historical, current, and forecasted Post-Bariatric Hypoglycemia epidemiology trends in the seven major countries (7MM) from 2019 to 2032. It helps to recognize the causes of current and forecasted Post-Bariatric Hypoglycemia epidemiology trends by exploring numerous studies and research. The epidemiology section also provides a detailed analysis of diagnosed and prevalent patient pools, future trends, and views of key opinion leaders.
The Report Covers the Post-Bariatric Hypoglycemia Epidemiology, Segmented as –
Type-Specific Bariatric Surgery Cases
Total Post-Bariatric Hypoglycemia (PBH) Cases
Post-Bariatric Hypoglycemia (PBH) Cases in Different Types of Bariatric Surgeries
Severity-specific Post-Bariatric Hypoglycemia (PBH) Cases
Total Treated Cases of Post-Bariatric Hypoglycemia (PBH) in the 7MM
Post-Bariatric Hypoglycemia Drugs Uptake and Pipeline Development Activities
The drug uptake section focuses on the uptake rate of potential drugs recently launched in the Post-Bariatric Hypoglycemia market or expected to be launched during the study period. The analysis covers the Post-Bariatric Hypoglycemia market uptake by drugs, patient uptake by therapies, and sales of each drug. Moreover, the therapeutics assessment section helps understand the market dynamics by drug sales, the most rapid drug uptake, and the reasons behind the maximal use of particular drugs. Additionally, it compares the Post-Bariatric Hypoglycemia drugs based on their sale and market share.
The report also covers the Post-Bariatric Hypoglycemia pipeline development activities. It provides valuable insights about different therapeutic candidates in various stages and the key Post-Bariatric Hypoglycemia companies involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.
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Post-Bariatric Hypoglycemia Therapeutics Analysis
As no approved therapies are available in the market, there is a huge opportunity for pharmaceutical firms to develop targeted and effective therapies for treating Post-Bariatric hypoglycemia. The use of off-label therapies is limited by poor tolerability and lack of efficacy.
Medical nutritional therapy is the first line of treatment for PBH. A strategy of consuming small portions of low glycemic index carbohydrates (30 g of carbohydrates per meal, 15 g per snack), adequate protein consumption (30 g per meal and total of 60–80 g/day), adequate fat consumption (15 g/meal, 5 g/snack), spacing meals 3–4 h apart, avoidance of alcohol, caffeine, and fluids with meals is recommended.
Surgical management may be considered for patients with moderate-to-severe symptoms refractory to nutritional therapy and pharmacotherapy. As with pharmacotherapy, large-scale trials comparing efficacy and safety are yet to be performed; surgical modality depends on the clinician’s preference/expertise, comorbidities, anatomy, and patient choice. Hypoglycemia is a challenging diagnosis.
Post-Bariatric Hypoglycemia Companies Actively Working in the Therapeutics Market Include
And Many Others
Emerging and Marketed Post-Bariatric Hypoglycemia Therapies Covered in the Report Include:
Avexitide: Eiger Biopharmaceuticals
And Many More
Other than the above-mentioned therapies, companies such as Zealand Pharma are developing a dasiglucagon mini-dose pen for the potential treatment of exercise-induced hypoglycemia in people living with T1D and for people who suffer from meal-induced hypoglycemia following gastric bypass surgery (post-bariatric hypoglycemia, or PBH).
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Table of Content (TOC)
1. Key Insights
2. Executive Summary
3. Post-Bariatric Hypoglycemia Competitive Intelligence Analysis
4. Post-Bariatric Hypoglycemia Market Overview at a Glance
5. Post-Bariatric Hypoglycemia Disease Background and Overview
6. Post-Bariatric Hypoglycemia Patient Journey
7. Post-Bariatric Hypoglycemia Patient Population and Epidemiology Trends (In the US, EU5, and Japan)
8. Post-Bariatric Hypoglycemia Treatment Algorithm, Current Treatment, and Medical Practices
9. Post-Bariatric Hypoglycemia Unmet Needs
10. Key Endpoints of Post-Bariatric Hypoglycemia Treatment
11. Post-Bariatric Hypoglycemia Marketed Therapies
12. Post-Bariatric Hypoglycemia Emerging Drugs and Latest Therapeutic Advances
13. Post-Bariatric Hypoglycemia Seven Major Market Analysis
14. Attribute Analysis
15. Post-Bariatric Hypoglycemia Market Outlook (In US, EU5, and Japan)
16. Post-Bariatric Hypoglycemia Companies Active in the Market
17. Post-Bariatric Hypoglycemia Access and Reimbursement Overview
18. KOL Views on the Post-Bariatric Hypoglycemia Market
19. Post-Bariatric Hypoglycemia Market Drivers
20. Post-Bariatric Hypoglycemia Market Barriers
22. DelveInsight Capabilities
*The Table of Contents (TOC) is not exhaustive; the final content may vary. Refer to the sample report for the complete table of contents.
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