Recently, Creative Biolabs, a professional biotechnology company with a rich-experienced team, has released a brand new drug module, aiming to help global clients prepare innovated payload-linker complexes for novel ADC developments.
Antibody-drug conjugates (ADCs) are next-generation targeted anti-tumor agents that are constructed by the covalent coupling of a monoclonal antibody with a cytotoxic payload drug via a small molecular linker. As a key factor in an ADC, the payload drug dictates its efficacy. At this moment, a large variety of payload drugs have been exploited in ADC and the number is on the rise.
“A suitable ADC payload should be small in size to minimize the risk of immunogenicity and have decent water solubility to facilitate the aqueous conjugation reactions. It should exert extremely high cytotoxic efficacy and adequate plasma stability to maintain drug efficacy before reaching the target”, said Dr. Monika Müller, Scientific Officer of Creative Biolabs.
“Based on these criteria, our team provide many payloads for our clients, including microtubule toxins, DNA toxins, as well as DNA transcription toxins. As an essential component of any therapeutic ADC, these payloads have been identified and developed into ADCs.”
With our well-established “DrugLnk” organic synthesis platform, the experienced scientists here at Creative Biolabs is dedicated to helping you prepare various customized payload-linker complexes using toxins in the Drug Module for ADC development in a timely and cost-effective manner.
About Creative Biolabs
Established in 2004, Creative Biolabs is highly specialized in advanced antibody biochemistry and engineering. With more than a decade of exploration and expansion, our current research and service capacity covers the entire new drug discovery and development pipeline, ranging from early discovery, preclinical evaluations, cGMP manufacturing, to clinical trials. As an international cooperation, we have established offices all around the globe with more than 200 well-trained full-time scientists and technicians, who work closely with our customers and research partners to develop new medicines for a better, healthier world.
Company Name: Creative Biolabs
Contact Person: Bella Smith
Address:45-1 Ramsey Road
State: New York
Country: United States