Hydroxypropyl beta-cyclodextrin, also known as (2-hydroxypropyl) -β-cyclodextrin, is a hydrogen atom in the 2-, 3-, and 6-hydroxyl groups of the glucose residues in β-cyclodextrin (β-CD) that is replaced by hydroxypropyl to hydroxypropoxy. HP-β-CD not only has excellent envelope effect on many compounds like β-CD, but also has the advantages of high water solubility and improving the release rate and bioavailability of the encapsulated drugs in vivo. In addition, HP-β-CD is a drug excipient with the most extensive safety data collected and no adverse side effects. HP-β-CD can also be used as a protein protector and stabilizer.
Hydroxypropyl beta-cyclodextrin is white or white amorphous or crystalline powder; Odorless, slightly sweet; Strong moisture induction. This product is easily soluble in water, easily soluble in methanol, ethanol, almost insoluble in acetone, trichloromethane.
The solubility of hydroxypropyl -B-cyclodextrin in water is very good, and the substitution degree of 4 and above can be miscible with water in any proportion, and can also be dissolved in 50% ethanol and methanol. It has certain relative hygroscopicity. But the relative surface activity and hemolytic activity are relatively low. It has no irritation to muscle and is an ideal solvent enhancer and pharmaceutical excipient for injection.
What is Hydroxypropyl beta-cyclodextrin used for？
In the field of food and spices
Hydroxypropyl beta-cyclodextrin can improve the stability and long-term performance of nutritional molecules, cover up or correct the bad odor and taste of food nutritional molecules, and improve the production process and product quality.
The raw materials of cosmetics can be used as stabilizers, emulsifiers, deodorizers, etc., which can reduce the stimulation of organic molecules in cosmetics on skin and mucous membrane tissues, enhance the stability of active ingredients, and prevent the volatilization and oxidation of nutrients. It has a certain relative hygroscopicity.
In the field of medicine
Hydroxypropyl beta-cyclodextrin can improve the water solubility of insoluble drugs, increase drug stability, improve drug bioavailability, increase the efficacy of drug preparations or reduce the dosage, adjust or control the release speed of drugs, and reduce drug toxicity. It can be used as a carrier of oral drugs, injections, mucosal drug delivery systems (including nasal mucosa, rectum, cornea, etc.), transdermal absorption drug delivery systems, lipophilic targeted drugs, and can also be used as a protein protector and stabilizer.
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