New York, US–Nov 20, 2018 Over the past decade, Creative Biolabs has established its leadership in recombinant antibody discovery and manufacturing. With its top-notch medical technology and equipment, the company is capable of offering a wide range of single-chain variable fragment (scFv) antibody products and services.
The scFv fragment antibody is a type of small-molecular antibody, made up of VH and VL domains. This antibody weighing approximately 25 kDa accounts for 1/6 of the full length antibody. Thanks to its huge potential for anti-tumor immunotherapy, the scFv fragment antibody has been rather popular in the antibody generation field. Furthermore, the production of high-quality antibodies has solicited much attention from the industry and academia.
“It is extremely important to produce the scFv fragment antibody, because it has plenty of overwhelming advantages. First, it is easy to construct and express the scFv antibody, which allows for its large-scale preparation. In the past, the scFv antibodies have been constructed mainly based on hybridoma, spleen cells from immunized mice, and B lymphocytes from humans. Nowadays, they can be produced in bacterial cell cultures, unlike the monoclonal antibodies that are often produced in mammalian cell cultures. Second, this type of antibody performs quite well in penetrating the blood vessel wall and the solid tumor. As a result, it is usually chosen as the preferable carrier of targeting drugs. Third, the scFv antibody is unlikely to result in its receptor’s hypersensitivity and rejection. Fourth, if necessary, it can be eliminated in vivo immediately, thereby reducing the potential damages to surrounding tissues.” stated a scientist from Creative Biolabs when asked about the advantages of the scFv fragment antibody.
Actually, the scFv is not a fragment of an antibody, but a fusion protein in the variable regions of the heavy (VH) and light chains (VL) of immunoglobulins. The scFv antibody can also be genetically fused with the marker proteins, including fluorescent proteins and alkaline phosphatase. Given the antigen-binding capacity and marker activity, the resulting bifunctional proteins can be extracted from transformed bacteria and applied to the immunodetection of biological agents. In addition, the antibody fragments can also be utilized to help construct immunotoxins, deliver therapeutic genes and manufacture anticancer intrabodies for therapeutic purposes.
There is no denying that the scFv antibody has become an indispensable part in the immunotherapy against cancers. The advent of miscellaneous scFv antibodies from Creative Biolabs is bound to speed up their wider and more in-depth applications to the anti-tumor therapy. It is predicted that the scFv antibodies will make more contributions to the treatment of more obstinate human diseases.
About Creative Biolabs
With cutting-edge hybridoma development and phage display platforms, Creative Biolabs is committed to providing professional custom antibody discovery and engineering services, featuring phage display library construction, antibody humanization, chimerization, antibody labeling, hybridoma/stable cell line development, membrane protein production and cGMP-manufacturing, etc.
Company Name: Creative Biolabs
Contact Person: Bella Smith
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Address:45-1 Ramsey Road
State: New York
Country: United States