Nk Cell Therapy Pipeline constitutes 140+ key companies continuously working towards developing 160+ Nk Cell Therapy treatment therapies, analyzes DelveInsight.
Nk Cell Therapy Overview:
Natural Killer (NK) cells are a type of lymphocyte essential to the innate immune system, responsible for identifying and eliminating tumor cells and virus-infected cells. They contain cytotoxic granules filled with proteins such as perforins and granzymes, which trigger apoptosis in their targets. NK cells originate from common lymphoid progenitor cells and mature in organs like the bone marrow, thymus, and spleen before circulating in the bloodstream.
They can migrate into tissues and are activated by interleukins, which enable them to secrete cytokines and help regulate immune responses. NK cells achieve self-tolerance by recognizing self MHC class I molecules and can differentiate into organ-specific subsets, such as those found in the liver and uterus.
Their activity is tightly regulated by a balance between activating and inhibitory receptors. NK cells become activated when they detect abnormalities like decreased MHC class I expression or stress-induced ligands—signals commonly associated with infections or cancer.
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“Nk Cell Therapy Pipeline Insight 2025” report by DelveInsight provides a comprehensive analysis of the ongoing clinical development activities and growth prospects across the Nk Cell Therapy Therapeutics Market.
Key Takeaways from the Nk Cell Therapy Pipeline Report
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DelveInsight’s Nk Cell Therapy pipeline report depicts a robust space with 140+ active players working to develop 160+ pipeline therapies for Nk Cell Therapy treatment.
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October 2024: ImmunityBio announced that the first patients have been dosed in an initial trial evaluating its CAR-NK cell therapy targeting CD-19 for the treatment of non-Hodgkin’s lymphoma (NHL).
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July 2024: Nkarta received FDA approval to initiate a clinical trial for its cell therapy candidate, NKX019, in patients with ANCA-associated vasculitis (AAV) and other autoimmune diseases.
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May 2024: KGen Biotech’s Safety Review Committee approved the progression of its cryopreserved autologous NK cell therapy, SNK01, into Phase II clinical trials.
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May 2024: Fate Therapeutics announced that a late-breaking abstract featuring preclinical data from its FT522 program for autoimmune diseases will be presented at the ASGCT 27th Annual Meeting.
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April 2024: Sanofi advanced its NK cell engager candidate, SAR443579/IPH6101, to a Phase II trial for the treatment of various blood cancers.
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April 2024: The FDA granted orphan drug designation to IGNK001 (Gengleucel), an investigational therapy for acute myeloid leukemia (AML).
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Key Nk Cell Therapy companies such as Amgen, Innate Pharma, ImmunityBio, Dragonfly Therapeutics, Glycostem Therapeutics, Athenex, Takeda, Wugen, Affimed Therapeutics, VERAXA, Asclepius Technology Company Group, NKGen Biotech, Sanofi, Indapta Therapeutics, Celularity, GT Biopharma, Biohaven Pharmaceuticals, Acepodia, Allife Medical Science and Technology, Bright Path Biotherapeutics, and others are evaluating new drugs for Nk Cell Therapy to improve the treatment landscape.
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Promising Nk Cell Therapy pipeline therapies in various stages of development include Bemarituzumab, Monalizumab, L1 t-haNK, M ceNK, DF6002, oNKord, KUR-501, and others.
Nk Cell Therapy Pipeline Analysis
The report provides insights into:
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The report provides detailed insights into the key companies that are developing therapies in the Nk Cell Therapy Market.
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The report also evaluates different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Nk Cell Therapy treatment.
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It analyzes the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
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It navigates the emerging drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
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Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement, and financing details for future advancement of the Nk Cell Therapy market.
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Nk Cell Therapy Emerging Drugs
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Bemarituzumab: Amgen
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Monalizumab: Innate Pharma
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L1 t-haNK: ImmunityBio
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M ceNK: ImmunityBio
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DF6002: Dragonfly Therapeutics
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oNKord: Glycostem Therapeutics
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KUR-501: Athenex
Nk Cell Therapy Companies
Approximately 75 key companies are actively working on developing NK cell therapies. Among them, Carsgen Therapeutics has a drug candidate that has reached the most advanced stage—Registered.
DelveInsight’s report covers around 160+ products under different phases of clinical development like
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Late stage products (Phase III)
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Mid-stage products (Phase II)
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Early-stage product (Phase I) along with the details of
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Pre-clinical and Discovery stage candidates
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Discontinued & Inactive candidates
Nk Cell Therapy pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
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Intravenous
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Subcutaneous
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Oral
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Intramuscular
Nk Cell Therapy Products have been categorized under various Molecule types such as
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Monoclonal antibody
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Small molecule
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Peptide
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Nk Cell Therapy Pipeline Therapeutic Assessment
• Nk Cell Therapy Assessment by Product Type
• Nk Cell Therapy By Stage
• Nk Cell Therapy Assessment by Route of Administration
• Nk Cell Therapy Assessment by Molecule Type
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Table of Content
1. Report Introduction
2. Executive Summary
3. Nk Cell Therapy Current Treatment Patterns
4. Nk Cell Therapy – DelveInsight’s Analytical Perspective
5. Therapeutic Assessment
6. Nk Cell Therapy Late-Stage Products (Phase-III)
7. Nk Cell Therapy Mid-Stage Products (Phase-II)
8. Early Stage Products (Phase-I)
9. Pre-clinical Products and Discovery Stage Products
10. Inactive Products
11. Dormant Products
12. Nk Cell Therapy Discontinued Products
13. Nk Cell Therapy Product Profiles
14. Nk Cell Therapy Key Companies
15. Nk Cell Therapy Key Products
16. Dormant and Discontinued Products
17. Nk Cell Therapy Unmet Needs
18. Nk Cell Therapy Future Perspectives
19. Nk Cell Therapy Analyst Review
20. Appendix
21. Report Methodology
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