DelveInsight’s ‘LAG-3-Next Generation Immunotherapy—Competitive Landscape and Market Forecast–2035’ report delivers an in-depth understanding of the LAG-3 as well as the market trends of LAG-3-Next Generation Immunotherapy in the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan.
The report provides the upcoming drugs, market share of this target by indications, forecasted market size of LAG-3-Next Generation Immunotherapy from 2023 to 2035 segmented by seven major markets. This report discusses the recent findings on LAG-3, the role it plays in regulating immune responses in different cell types and the rationale for targeting LAG-3 for effective cancer immunotherapy. The report also covers the current scenario, market drivers, market barriers and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.
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LAG-3-Next Generation Immunotherapy Overview
Cancer immunotherapy (CI) is rapidly advancing and can now be considered to be the “fifth pillar” of cancer therapy, joining the ranks of surgery, cytotoxic chemotherapy, radiation, and targeted therapy. The CI which has sparked the most interest involves antibodies to inhibitory immune checkpoint molecules. Fighting cancer with immunotherapy has revolutionized treatment for some patients and therapies targeting the immune checkpoint molecules such as CTLA-4 and PD-1 have achieved durable responses in melanoma, renal cancer, Hodgkin’s diseases and lung cancer. However, the success rate of these treatments has been low and a large number of cancers, including colorectal cancer remain largely refractory to CTLA-4 and PD-1 blockade.
Lymphocyte-activation gene 3 (LAG-3) is an immune checkpoint receptor protein found on the cell surface of effector T cells and regulatory T cells (Tregs) and functions to control T cell response, activation, and growth. T cells are a type of white blood cell that are part of the immune system. Activation of cytotoxic T cells by antigens enables them to kill unhealthy or foreign cells. It binds MHCII molecules and modulates T-cell function than either CTLA-4 or PD-1. It acts by regulating CD8+ Tcell expansion in immune reactions that have already been initiated (inhibitory signal) and also, by increasing the Treg cell activity.
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1. MGD013: MacroGenics
2. LAG525: Novartis
3. Relatlimab (BMS-986016): Bristol-Myers Squibb
4. Eftilagimod Alpha (IMP321): Immutep
5. MK-4280: Merck
Lag-3-Next Generation Immunotherapy Market
The LAG-3-Next Generation Immunotherapy market outlook helps to cultivate a detailed comprehension of the historical, current and forecasted market trends by analyzing the market, unmet needs, drivers and barriers, and demand for better technology.
This segment gives a thorough detail of LAG-3-Next Generation Immunotherapy market trend of each late-stage pipeline therapy by evaluating their impact based on the annual cost of treatment, inclusion and exclusion criteria’s, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market, and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to give a clear picture of the market at first sight.
According to DelveInsight, the LAG-3-Next Generation Immunotherapy market is expected to generate USD 7,009 Million in the year 2035 with a significant CAGR in the forecast period (2023─2035).
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Some of the key Lag-3-Next Generation Immunotherapy companies operating in the Lag-3-Next Generation Immunotherapy market include MacroGenics, Zai Lab, Novartis, Bristol-Myers Squibb, Ono Pharmaceuticals, Immutep, Novartis, Merck, Regeneron, F-star Therapeutics, Xencor, and others.
Table of Contents
1. Key Insights
2. Executive Summary
3. Competitive Intensity of LAG-3-Next Generation Immunotherapy
4. Market Competition of LAG-3-Next Generation Immunotherapy
5. Technological innovations in LAG-3-Next Generation Immunotherapy
6. Multivariate analysis of the key players in LAG-3-Next Generation Immunotherapy
7. LAG-3-Next Generation Immunotherapy Market Overview at a Glance
8. Pipeline Therapeutics Analysis (Active Products)
9. Overview: Next Generation Immunotherapy
10. Future Prospects and Challenges in LAG-3-Next Generation Immunotherapy
11. SWOT Analysis
12. Epidemiology and Forecasting Assumptions
13. Emerging Drugs
14. Assessment by Indication
15. Assessment by Route of Administration
16. Assessment by Stage and Indication
17. Assessment by stage and Route of Administration
18. LAG-3-7 Major Market Analysis
19. Market Drivers
20. Market Barriers
22. DelveInsight Capabilities
24. About DelveInsight
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