The Ischemic Stroke Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. The report also covers a detailed description of the drug, including the mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, collaborations, mergers acquisition, funding, designations, and other product-related details.

“Ischemic Stroke Pipeline Insight, 2023“ report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the Ischemic Stroke Market.

Some of the key takeaways from the Ischemic Stroke Pipeline Report:

• Companies across the globe are diligently working toward developing novel Ischemic Stroke treatment therapies with a considerable amount of success over the years. 
• Ischemic Stroke companies working in the treatment market are TargED Biopharmaceuticals, Saillant Therapeutics, AbbVie, Revalesio Corporation, Biogen, Acticor Biotech, ZZ Biotech, GNT Pharma, Athersys, Inc., Acticor Biotech, Lumosa Therapeutics, Avilex Pharma, and others, are developing therapies for the Ischemic Stroke treatment 

• Emerging Ischemic Stroke therapies in the different phases of clinical trials are- Microlyse, ST-01, Elezanumab, RNS60, BIIB131, Glenzocimab, 3K3A-APC, Nelonemdaz, MultiStem, Glenzocimab, LT3001, AVLX-144, and others are expected to have a significant impact on the Ischemic Stroke market in the coming years.   
• In July 2022, ACTICOR BIOTECH disclosed that its drug candidate, glenzocimab, obtained “PRIority Medicines” designation from the European Medicines Agency (EMA) for treating stroke patients. This designation facilitates Acticor Biotech in enhancing engagements and securing preliminary discussions with regulatory bodies to solidify the clinical development strategy for glenzocimab in stroke treatment.
• In July 2022, NervGen Pharma revealed that a groundbreaking preclinical study conducted by the University of Cincinnati and Case Western Reserve University (CWRU) has been published in the scientific journal Cell Reports. This study showcases the effectiveness of NervGen’s unique drug, NVG-291-R, in facilitating nervous system repair and notable functional recuperation in a mouse model of severe ischemic stroke. Notably, the treatment demonstrated significant recovery benefits even when initiated up to 7 days after the onset of the stroke.
• In June 2022, Pharmazz Inc has unveiled encouraging top-line outcomes from its Phase III clinical trial assessing sovateltide’s efficacy in treating acute ischemic stroke. The results highlighted a notable increase, at the 90-day mark, in the number of participants showing a significant improvement of 2 points or more on the modified Rankin Score (mRS), a substantial reduction in the median score on the mRS, and a considerable decrease in the number of individuals displaying an improvement of 6 or more points on the NIHSS Level of Consciousness (1A)
• In February 2022, Acticor Biotech disclosed encouraging results derived from its Phase Ib/IIa ACTIMIS clinical trial evaluating glenzocimab as an adjunctive therapy alongside the standard care for acute ischemic stroke (AIS) patients. The findings indicated the trial successfully achieved its primary objective by confirming the favorable safety profile of glenzocimab.
• In February 2022, Bayer revealed that the U.S. Food and Drug Administration (FDA) has provided Fast Track Designation for its experimental drug asundexian (BAY2433334) concerning its potential application as a treatment for secondary prevention among patients who have experienced a non-cardioembolic ischemic stroke.
• In May 2022, Athersys, Inc. disclosed that its collaborator, HEALIOS K.K. (Healios), released the key findings from its Japan-based ischemic stroke study, TREASURE. The study revealed notable improvements in predetermined functional measures associated with “independence” and positive outcomes such as mRS ≤2, Barthel Index ≥95, and Global Recovery linked to MultiStem treatment. However, the primary endpoint of achieving an excellent outcome at 90 days did not demonstrate statistical significance in the overall population. Importantly, there were no substantial differences observed in safety outcomes, including mortality and life-threatening adverse events, between the treatment and placebo groups.

Ischemic Stroke Overview

An ischemic stroke, also known as a brain attack, happens when a blood artery in the brain breaks or when something stops the blood supply to a portion of the brain. Either way, certain brain regions suffer harm or even die. A stroke can result in death, long-term incapacity, or permanent brain damage.

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Emerging Ischemic Stroke Drugs Under Different Phases of Clinical Development Include:

• Microlyse: TargED Biopharmaceuticals
• ST-01: Saillant Therapeutics
• Elezanumab: AbbVie
• RNS60: Revalesio Corporation
• BIIB131: Biogen
• Glenzocimab: Acticor Biotech
• 3K3A-APC: ZZ Biotech
• Nelonemdaz: GNT Pharma
• MultiStem: Athersys, Inc.
• Glenzocimab: Acticor Biotech
• Elezanumab: AbbVie
• LT3001: Lumosa Therapeutics
• AVLX-144: Avilex Pharma

Ischemic Stroke Route of Administration

Ischemic Stroke pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs, such as 

• Oral
• Intravenous
• Subcutaneous
• Parenteral
• Topical

Ischemic Stroke Molecule Type

Ischemic Stroke Products have been categorized under various Molecule types, such as

• Recombinant fusion proteins
• Small molecule
• Monoclonal antibody
• Peptide
• Polymer
• Gene therapy

Ischemic Stroke Pipeline Therapeutics Assessment

• Ischemic Stroke Assessment by Product Type
• Ischemic Stroke By Stage and Product Type
• Ischemic Stroke Assessment by Route of Administration
• Ischemic Stroke By Stage and Route of Administration
• Ischemic Stroke Assessment by Molecule Type
• Ischemic Stroke by Stage and Molecule Type

DelveInsight’s Ischemic Stroke Report covers around 55+ products under different phases of clinical development like

• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I)
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

Further Ischemic Stroke product details are provided in the report. Download the Ischemic Stroke pipeline report to learn more about the emerging Ischemic Stroke therapies

Some of the key companies in the Ischemic Stroke Therapeutics Market include:

Key companies developing therapies for Ischemic Stroke are – Bristol-Myers Squibb, NuvOX Pharma, Simcere Pharmaceutical Co., Ltd., Genentech, Inc., NoNO Inc., Pharming Technologies B.V., Biogen, Athersys, Inc., Tarveda Therapeutics, Nanjing Yoko Biomedical Co., Ltd., TrueBinding, Inc., GNT Pharma, Roche, DiaMedica Therapeutics Inc, aptaTargets, Avilex Pharma, Lumosa Therapeutics, NC Medial Research Inc, Acticor Biotech, Meridigen Biotech Co., Prolong Pharmaceuticals, SanBio, ZZ Biotech, Revalesio, Stemedica Cell Technologies, StemCyte, Ninnion, Algernon Pharmaceuticals, Primary Peptides, TMS, Tasly Pharmaceutical, Pharmazz and others.

Ischemic Stroke Pipeline Analysis:

The Ischemic Stroke pipeline report provides insights into 

• The report provides detailed insights about companies that are developing therapies for the treatment of Ischemic Stroke with aggregate therapies developed by each company for the same.
• It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Ischemic Stroke Treatment.
• Ischemic Stroke key companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
• Ischemic Stroke Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type. 
• Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Ischemic Stroke market.

The report is built using data and information traced from the researcher’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations, and featured press releases from company/university websites and industry-specific third-party sources, etc.

Download Sample PDF Report to know more about Ischemic Stroke drugs and therapies

Ischemic Stroke Pipeline Market Drivers

• Rising incidence of Acute Ischemic Stroke, increasing prevalence of lifestyle associated disorders such as diabetes and hypertension, rising geriatric population are some of the important factors that are fueling the Ischemic Stroke Market.

Ischemic Stroke Pipeline Market Barriers

• However, challenges associated with the clinical research, challenges with the diagnosis of AIS and other factors are creating obstacles in the Ischemic Stroke Market growth.

Scope of Ischemic Stroke Pipeline Drug Insight    

• Coverage: Global
• Key Ischemic Stroke Companies: TargED Biopharmaceuticals, Saillant Therapeutics, AbbVie, Revalesio Corporation, Biogen, Acticor Biotech, ZZ Biotech, GNT Pharma, Athersys, Inc., Acticor Biotech, Lumosa Therapeutics, Avilex Pharma, and others
• Key Ischemic Stroke Therapies: Microlyse, ST-01, Elezanumab, RNS60, BIIB131, Glenzocimab, 3K3A-APC, Nelonemdaz, MultiStem, Glenzocimab, LT3001, AVLX-144, and others
• Ischemic Stroke Therapeutic Assessment: Ischemic Stroke current marketed and Ischemic Stroke emerging therapies
• Ischemic Stroke Market Dynamics: Ischemic Stroke market drivers and Ischemic Stroke market barriers 

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Table of Contents

1. Ischemic Stroke Report Introduction

2. Ischemic Stroke Executive Summary

3. Ischemic Stroke Overview

4. Ischemic Stroke- Analytical Perspective In-depth Commercial Assessment

5. Ischemic Stroke Pipeline Therapeutics

6. Ischemic Stroke Late Stage Products (Phase II/III)

7. Ischemic Stroke Mid Stage Products (Phase II)

8. Ischemic Stroke Early Stage Products (Phase I)

9. Ischemic Stroke Preclinical Stage Products

10. Ischemic Stroke Therapeutics Assessment

11. Ischemic Stroke Inactive Products

12. Company-University Collaborations (Licensing/Partnering) Analysis

13. Ischemic Stroke Key Companies

14. Ischemic Stroke Key Products

15. Ischemic Stroke Unmet Needs

16 . Ischemic Stroke Market Drivers and Barriers

17. Ischemic Stroke Future Perspectives and Conclusion

18. Ischemic Stroke Analyst Views

19. Appendix

20. About DelveInsight

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate business growth and overcome challenges with a practical approach.

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