Gout Pipeline Assessment | Insights Into the Marketed and Emerging Therapies, Latest Regulatory Approvals, Clinical Trials, Treatment Outlook, Key Companies

Gout Pipeline Assessment | Insights Into the Marketed and Emerging Therapies, Latest Regulatory Approvals, Clinical Trials, Treatment Outlook, Key Companies
Gout Pipeline

Around 40+ key companies are developing therapies for Gout. Selecta Biosciences appears to have the upper leg being the only company with its Gout drug candidate in the most advanced stage (Phase III).

 

DelveInsight’s Gout Pipeline Insights report offers comprehensive coverage of the emerging Gout therapeutics landscape in different stages of development from pre-clinical till a late-end stage, along with dormant, inactive, and abandoned drugs agents. 

The Gout Pipeline report provides a holistic picture of the ongoing clinical trials, partnerships taking place in the domain, recent happenings in space, and growth prospects across the Gout domain.

 

 

Some of the key highlights from the Gout Pipeline report:

  • The Gout Pipeline report offers a rich analysis of 40+ key players and 40+ key therapies.
  • Gout pipeline comprises therapies in different stages of the clinical phase such as include PRX-115, SAP-001, HZN-003, URC-102, SHR4640, NC-2700, XNW3009, LC350189, SEL-212, AC-201, Dapansutrile, HP501, DYV700, D-0120,  ARO-XDH, WT-2107, ACQT1127, TJC0434, ABP-072, and others, with many others expected to enter the Gout market in the next decade. 
  • Some of the key companies engaged in strengthening the Gout Pipeline are Protalix BioTherapeutics, Shanton Pharma, Horizon Therapeutics, JW Pharmaceutical, Jiangsu Hengrui Medicine Co., Nippon Chemiphar, Sinovent, LG Chem, Selecta Biosciences, TWi Biotechnology, Olatec Therapeutics,  Hinova pharmaceuticals, Dyve Biosciences, InventisBio, Arrowhead Pharmaceuticals, Wellstat Therapeutics Corporation, Acquist Therapeutics, TaiwanJ Pharmaceuticals, Atom Bioscience among others
  • In June 2020, Swedish Orphan Biovitrum AB and Selecta Biosciences, Inc. announced that the companies have entered into a strategic licensing agreement for the product candidate SEL-212. SEL-212 is a combination of Selecta’s tolerogenic ImmTOR immune tolerance platform and a therapeutic uricase enzyme (pegadricase) that is designed to durably control serum uric acid, reduce immunogenicity, and allow for repeated monthly dosing for the treatment of chronic refractory gout. This agreement represents an important milestone for Selecta, and for patients with chronic refractory gout, as Sobi is the ideal partner with the commitment, resources, and complementary product portfolio to advance SEL-212 through development and commercialization.
  • In May 2021, Fortress Biotech announced that it had entered into an exclusive licensing agreement with Fuji Yakuhin Co. Ltd. to develop Dotinurad in the United States, United Kingdom, European Union and Canada. Under the terms of the agreement, the Company acquired exclusive development and marketing rights in North America and Europe from Fuji. Fuji is eligible to receive upfront, development and commercial milestones and royalty payments from the Company. Fortress expects to leverage data from three completed Phase III clinical trials in more than 500 Japanese patients to develop and market Dotinurad.
  • In August 2021, Arthrosi Therapeutics announced a joint venture in Guangzhou China with Ruiao Biopharmaceutical Technology Co., Ltd. to form Guangzhou Ruianbo Pharmaceutical Technology Co., Ltd. The joint venture will be responsible for the development of AR882 in the greater China area (Mainland China, Hong Kong, Macao, and Taiwan) while Arthrosi Therapeutics, Inc. continues to lead the global development of AR882 in the gout and tophaceous gout population. In addition, the joint venture will allow Arthrosi to enter the precision medicine oncology therapeutic area by moving AR035, a potent EGFR exon 20 inhibitor targeting non-small cell lung cancer, into the IND-enabling stage.

 

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Gout is a chronic disease that is caused due to excess accumulation of uric acid in the body, a condition referred to as hyperuricemia. It is a painful and crystal-induced form of arthritis in which crystals of monosodium urate (MSU) precipitate and deposit in joints of lower limbs. Gout is treatable with medications and changes in diet and lifestyle.

 

Gout Pipeline Drugs

Drug

Company

Phase

MoA

RoA

SEL-212

Selecta Biosciences

Phase III

Urate oxidase replacements

Intravenous

SHR4640

Jiangsu Hengrui Medicine Co.

Phase III

SLC22A12 protein inhibitors

Oral

LC350189

LG Chem

Phase II

Xanthine oxidase inhibitors

Oral

URC-102

JW Pharmaceutical 

Phase II

SLC22A12 protein inhibitors

Oral

Dapansutrile

Olatec Therapeutics

Phase II

Inflammasome inhibitors; Interleukin inhibitors; NLRP3 protein inhibitors

Oral

TMX-049

Teijin Pharma

Phase II

Xanthine oxidase inhibitors

NA

SAP-001

Shanton Pharma

Phase II

Urate transporter inhibitors

Oral

XNW3009

Sinovent

Phase I

SLC22A12 protein inhibitors

Oral

PRX-115

Protalix BioTherapeutics

Preclinical

Urate oxidase replacements

Intravenous

NC-2700 

Nippon Chemiphar

Preclinical

SLC22A12 protein inhibitors

NA

HZN-003

Horizon Therapeutics

Preclinical

Enzyme replacements

Subcutaneous

 

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Gout Therapeutic Assessment

The Gout Pipeline report lays down complete insights into active Gout pipeline therapies segmented by Stage, Product Type, Route of Administration, Molecule Type, Target, and Mechanism of Action.

 

Scope of the Report

Coverage: Global Key Players: Protalix BioTherapeutics, Shanton Pharma, Horizon Therapeutics, JW Pharmaceutical, Jiangsu Hengrui Medicine Co., Nippon Chemiphar, Sinovent, LG Chem, Selecta Biosciences, TWi Biotechnology, Olatec Therapeutics, Hinova pharmaceuticals, Dyve Biosciences, InventisBio, Arrowhead Pharmaceuticals, Wellstat Therapeutics Corporation, Acquist Therapeutics, TaiwanJ Pharmaceuticals, Atom Bioscience

Key Gout Pipeline Therapies: PRX-115, SAP-001, HZN-003, URC-102, SHR4640, NC-2700, XNW3009, LC350189, SEL-212, AC-201, Dapansutrile, HP501, DYV700, D-0120, ARO-XDH, WT-2107, ACQT1127, TJC0434, ABP-072, and many others.

 

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Table of Contents 

1

Report Introduction

2

Gout Disease Overview

3

Gout Pipeline Outlook

4

 Comparative Analysis

5

Gout Therapeutic Products in Clinical Stage

6

Gout Late Stage Products (Phase III)

6.1

SEL-212: Selecta Biosciences

6.2

SHR4640: Jiangsu Hengrui Medicine Co.

7

Gout Mid Stage Products (Phase II)

7.1

LC350189: LG Chem

7.2

URC-102: JW Pharmaceutical

7.3

SAP-001: Shanton Pharma

8

Gout Early Stage Products (Phase I)

8.1

XNW3009: Sinovent

9

Gout Therapeutic Products in Non-clinical Stage

10

Gout Preclinical and Discovery Stage Products

10.1

HZN-003: Horizon Therapeutics

10.2

PRX-115: Protalix BioTherapeutics

11

Gout Therapeutics Pipeline Analysis

12

Inactive Gout Pipeline Products 

13

Appendix

14

 Report Methodology

15

Consulting Services

16

Disclaimer

17

About DelveInsight

 

About Delveinsight: 

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