Global Downstream Processing Market Size Projected to Reach USD 65.66 Billion By 2028: Polaris Market Research

Global Downstream Processing Market Size Projected to Reach USD 65.66 Billion By 2028: Polaris Market Research
According to the research report, the global downstream processing market size was valued at USD 21.36 billion in 2020 and is expected to reach USD 65.66 Billion By 2028, growing at a CAGR of 15.5% during the forecast period.

According to the research report, the global downstream processing market size was valued at USD 21.36 billion in 2020 and is expected to reach USD 65.66 Billion By 2028, growing at a CAGR of 15.5% during the forecast period.

What is Downstream Processing? How Big is Downstream Processing Market?

  • Overview


Downstream processing indicates recuperation and disinfection of biosynthetic products, especially pharmaceuticals from crude sources like a plant or animal tissue or fermentation broth, involving recycling of rectifiable components and suitable cure and waste disposal. It is a necessary step in producing pharmaceuticals like hormones, antibiotics, vaccines, and antibodies. Antibodies and enzymes are utilized in diagnostics, industrial enzymes, flavored compounds, and natural fragrances.

Purification commences with isolating the cells from the media. In most cultures that are mammalian, the protein is emitted into media. Therefore, supernatant must be gathered for additional purification. In microbial production, the protein can also assemble within the cells. Thus, there should be a disruption of cells and cell debris segregated from the protein of interest. Insolvable products involve unraveled, clear proteins adhering together, known as inclusion bodies must be inflexed to obtain their indigenous agility conformation.

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(The sample of this report is readily available on request. The report sample contains a brief introduction to the research report, a Table of Contents, a Graphical introduction of regional analysis, Top players in the market with their revenue analysis, and our research methodology.)

Objectives of the report

  • To study and inspect the global downstream processing market size by significant areas or countries, applications, product type, and history data
  • To comprehend the structure of the downstream processing market by recognizing its several sub-segments
  • Concentration on the significant global downstream processing players to elucidate, recount and scrutinize their value, development plans, market share in the subsequent few years
  • To scrutinize the downstream processing in context to personal growth trends, expectations, and their benefaction to the entire market
  • To split information that is detailed about significant factors impacting the maturity of the market
  • To calculate the size of downstream processing submarkets in the context of significant regions


Top Market Players Are:

  • 3M Company
  • Danaher Corporation
  • Ashai Kasei
  • Corning Corporation
  • Lonza Group Ltd
  • Boehringer Ingelheim International GmbH
  • Dover Corporation
  • Eppendorf AG
  • Ferner PLC
  • Merck KGaA
  • GE Healthcare
  • Sartorius Stedim Biotech S.A
  • Thermo Fisher Scientific Inc.
  • Repligen


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Downstream processing market: Growth leading factors

A noteworthy development in the pharmaceutical industry worldwide is one of the essential factors generating a positive outlook for the market. Downstream processing is broadly utilized to purify, isolate, and focus the drug substance synthesized from the complicated bulk matrix. Additionally, the growing prevalence of several infectious diseases like hepatitis, dengue, and swine influenza pushes the market.

With the spread of coronavirus, there has been an incremental development in the usage of downstream processing to make the vaccines. The efficacy is higher, and side effects are minimal. Further several technological progressions like the advancement of imaginative multicomponent segregation and perfusion chromatography systems are behaving as alternative growth-inducing factors.

During the covid-19 pandemic, biopharmaceutical developers are at the cutting edge of the human response to the coronavirus pandemic. Many biotech companies are competing to deduce the Sars-Cov-2 genome and make a viable vaccine for the same, and a significant amount of funds are being injected into R&D.

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Downstream processing market: Report Scope

Report Attribute


Market Size 2020 Value

USD 21.36 billion

Market Outlook for 2028

USD 65.66 Billion

Expected CAGR Growth

15.5% from 2021 – 2028

Base year


Forecast period

2021 – 2028

Segments covered

By Product, By Technique, By Application, By Region

Key Companies

3M Company, Danaher Corporation, Ashai Kasei, Corning Corporation, Lonza Group Ltd, Boehringer Ingelheim International GmbH, Dover Corporation, Eppendorf AG, Ferner PLC, Merck KGaA, GE Healthcare, Sartorius Stedim Biotech S.A, Thermo Fisher Scientific Inc., and Repligen

Regional scope

North America, Europe, Asia Pacific, Latin America, Middle East & Africa

Customization Options

Customized purchase options are available to meet your research needs.


Downstream processing market: Key segmentation

  • Insight by product, technique, application, and region


By product, the chromatography systems segment dominated the market and accounted for the largest revenue share owing to constant R&D to enhance the efficacy and speed of the chromatography system. By technique, the purification by chromatography segment dominated the market because single-use chromatography and filtration systems are considered a benchmark in downstream bioprocessing. Therefore, the companies are undertaking strategies of business development like agreements or mergers and acquisitions to enlarge their portfolio. By application, the antibiotic production segment ruled the market due to extensive applications of antibiotics for curing many disorders.

North America emerged as a dominating region by region because the government supported encouraging bioprocess technology, growing medical spending, and advanced healthcare infrastructure. Further, the area saw main collective activities with giants of healthcare that are pervasively investing in the R&D of vaccines and biopharmaceuticals. In the Asia Pacific, the downstream processing market is anticipated to record the highest growth rate because of the increasing investments by consumers and developers in biotechnology. The large population base is pushing the requirement for advanced medical facilities, for which the players are determined to administer speedy analytical methods to underpin the design that is in process and bioprocessing.

Browse the full “Downstream Processing Market Share, Size, Trends, Industry Analysis Report, By Technique (Cell Disruption, Solid-liquid Separation, Concentration, Purification by Chromatography, Formulation); By Product; By Application; By Regions; Segment Forecast, 2021 – 2028” Report at

Important Questions Being Answered by The Market Report

  • What is the market size and growth?
  • What is the study period of this market?
  • Which region holds the highest growth rate in the downstream processing market?
  • Which region has the most significant share of the downstream processing market?
  • Who are the key players?
  • What are the factors driving the market?


The market primarily depends on the product, technique, application, and region

Downstream processing market: By product

  • Chromatography Systems
  • Filters
  • Evaporators
  • Centrifuges
  • Dryers
  • Others


Downstream processing market: By technique

  • Cell Disruption
  • Solid-liquid Separation
    • Filtration
    • Centrifugation
  • Concentration
    • Evaporation
    • Membrane Filtration
  • Purification by Chromatography
  • Formulation


Downstream processing market: By application

  • Antibiotic Production
  • Hormone Production
  • Antibodies Production
  • Enzyme Production
  • Vaccine Production


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