DelveInsight’s, “Diffuse Intrinsic Pontine Glioma Pipeline Insight, 2025” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Diffuse Intrinsic Pontine Glioma pipeline landscape. It covers the Diffuse Intrinsic Pontine Glioma pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Diffuse Intrinsic Pontine Glioma pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

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Key Takeaways from the Diffuse Intrinsic Pontine Pipeline Report

• In July 2025, InSightec conducted a study to evaluate the safety, feasibility and preliminary efficacy of Blood Brain Barrier Disruption (BBBD) using the Exablate Type 2 system in pediatric patients with Diffuse Intrinsic Pontine Glioma Gliomas (DIPG) undergoing Doxorubicin chemotherapy. The study will be conducted at up to three sites in the United States. Patients will undergo 3 treatment cycles, approximately 4-6 weeks apart. The study aims to establish feasibility and safety of Exablate BBBD in conjunction with Doxorubicin in the treatment of pediatric DIPG and assess preliminary efficacy in this patient population.
• In July 2025, Nationwide Children’s Hospital announced a study is to determine the efficacy of the study drugs ribociclib and everolimus to treat pediatric and young adult patients newly diagnosed with a high-grade glioma (HGG), including DIPG, that have genetic changes in pathways (cell cycle, PI3K/mTOR) that these drugs target.
• DelveInsight’s Diffuse Intrinsic Pontine Glioma Glioma pipeline report depicts a robust space with 10+ Diffuse Intrinsic Pontine Glioma Glioma companies working to develop 10+ pipeline therapies for Diffuse Intrinsic Pontine Glioma Glioma treatment.
• The leading Diffuse Intrinsic Pontine Glioma Glioma Companies such as FLAG Therapeutics, Avetabiomics, Brainchild Bio, Biodexa Pharmaceuticals, Kazia Therapeutics and others.
• Promising Diffuse Intrinsic Pontine Glioma Glioma Pipeline Therapies such as BXQ-350, ONC201, PTC596, Radiotherapy, AloCELYVIR, Temozolomide, Bevacizumab, Irinotecan, and others.

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Diffuse Intrinsic Pontine Glioma Emerging Drugs Profile

• MTX110: Biodexa Pharmaceuticals

MTX110 is a water-soluble formulation of panobinostat free base, achieved through complexation with hydroxypropyl-β-cyclodextrin (HPBCD), and designed for convection-enhanced delivery (CED) to deliver chemotherapeutic doses directly to brain tumors. Panobinostat, a hydroxamic acid and pan-histone deacetylase (HDAC) inhibitor, disrupts tumor growth by altering gene expression through inhibition of deacetylation processes. Unlike the oral formulation of panobinostat lactate (Farydak), which is limited by poor blood-brain barrier penetration, MTX110 bypasses this barrier by being administered directly into or around the tumor via catheter systems, such as CED or fourth ventricle infusions. Currently, the drug is in Phase I/II stage of its clinical trial for the treatment of DIPG.

• FLAG-003: FLAG Therapeutics

FLAG-003 is a water-soluble, small-molecule therapeutic designed to target and kill cancer cells through two key mechanisms of action: anti-angiogenesis and tubulin inhibition. By binding to three critical cell surface receptors—EGFR, VEGF-R2, and PDGFR-β—FLAG-003 inhibits tumor angiogenesis, cutting off the vascular structure essential for tumor growth. Simultaneously, it disrupts tubulin production, preventing cellular reproduction and inducing tumor cell death. With a remarkably low molecular weight, FLAG-003 can cross the blood-brain barrier (BBB) and evade detection by the Pgp-efflux pump, making it a promising candidate for treating gliomas such as Diffuse Intrinsic Pontine Glioma (DIPG) and Glioblastoma Multiforme (GBM).

The Cutaneous T-Cell Lymphoma pipeline report provides insights into

• The report provides detailed insights about companies that are developing therapies for the treatment of Diffuse Intrinsic Pontine Glioma with aggregate therapies developed by each company for the same.
• It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Diffuse Intrinsic Pontine Glioma Treatment.
• Diffuse Intrinsic Pontine Glioma Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
• Diffuse Intrinsic Pontine Glioma Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
• Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Diffuse Intrinsic Pontine Glioma market.

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Cutaneous T-Cell Lymphoma Glioma Companies

FLAG Therapeutics, Avetabiomics, Brainchild Bio, Biodexa Pharmaceuticals, Kazia Therapeutics and others.

Diffuse Intrinsic Pontine Glioma pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Intra-articular
• Intraocular
• Intrathecal
• Intravenous
• Oral
• Parenteral
• Subcutaneous
• Topical
• Transdermal

Diffuse Intrinsic Pontine Products have been categorized under various Molecule types such as,

• Oligonucleotide
• Peptide
• Small molecule

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Scope of the Diffuse Intrinsic Pontine Pipeline Report

• Coverage– Global
• Diffuse Intrinsic Pontine Glioma Companies- FLAG Therapeutics, Avetabiomics, Brainchild Bio, Biodexa Pharmaceuticals, Kazia Therapeutics and others.
• Diffuse Intrinsic Pontine Glioma Pipeline Therapies- BXQ-350, ONC201, PTC596, Radiotherapy, AloCELYVIR, Temozolomide, Bevacizumab, Irinotecan, and others.
• Diffuse Intrinsic Pontine Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
• Diffuse Intrinsic Pontine Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

For a detailed overview of our latest research findings and future plans, read the full details of Diffuse Intrinsic Pontine Pipeline on our website @ Diffuse Intrinsic Pontine Emerging Drugs and Companies

Table of Contents

1. Introduction
2. Executive Summary
3. Diffuse Intrinsic Pontine Glioma: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. Diffuse Intrinsic Pontine Glioma– DelveInsight’s Analytical Perspective
7. Late Stage Products (Phase III)
8. Drug name : Company name
9. Drug profiles in the detailed report…..
10. Mid Stage Products (Phase II)
11. Drug name : Company name
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I/II)
14. MTX110: Biodexa Pharmaceuticals
15. Drug profiles in the detailed report…..
16. Preclinical and Discovery Stage Products
17. FLAG-003: FLAG Therapeutics
18. Drug profiles in the detailed report…..
19. Inactive Products
20. Diffuse Intrinsic Pontine Glioma – Collaborations Assessment- Licensing / Partnering / Funding
21. Diffuse Intrinsic Pontine Glioma – Unmet Needs
22. Diffuse Intrinsic Pontine Glioma – Market Drivers and Barriers
23. Appendix

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