Cytokine release syndrome (CRS) is a systemic inflammatory response with outpouring of the inflammatory cytokines due to stimulus triggered by a variety of factors such as infections, immunotherapy, especially those involving T-cell engagers and certain other drugs. Even though cytokines acts to direct immune response, the higher levels of cytokines with increased inflammation can be harmful as they interfere with a number of body functions. In severe cases, CRS can cause organ failure in heart, lung, kidney, liver, and brain function that may even lead to death.
CRS is a potential life-threatening toxicity that has been frequently reported following administration of natural and bispecific antibodies and, adoptive T-cell engaging immunotherapies for cancer. It often begins with fever and flu-like symptoms but can worsen quickly and cause serious illness. The CRS severity is influenced by factors related to the type of therapy, the underlying disease, and characteristics of the patients.
The incidence of CRS in patients receiving cancer immunotherapy varies widely depending on the type of immunotherapeutic agent. The onset of CRS can occur within a few days, and in the case of CAR T cell therapy, up to several weeks after infusion of the drug. With most conventional monoclonal antibodies, the incidence of CRS is relatively low, whereas T cell-engaging cancer immunotherapies carry a particularly high risk of CRS. (Vornhagen et al.)
Get FREE sample copy at:
https://www.delveinsight.com/sample-request/cytokine-release-syndrome-epidemiology-forecast
The DelveInsight Cytokine Release Syndrome epidemiology report gives a thorough understanding of the Cytokine Release Syndrome by including details such as disease definition, symptoms, causes, pathophysiology, and diagnosis. It also provides treatment algorithms and treatment guidelines for Cytokine Release Syndrome in the US, Europe, and Japan.
The report covers the detailed information of the Cytokine Release Syndrome epidemiology scenario in seven major countries (US, EU5, and Japan).
Key Highlights Of The Report
The reported incidence of CRS after CAR T-cell therapy ranges from 50% to 100%, with 13% to 48% of patients experiencing the severe or life-threatening form.(Robert et al.)
It is being observed that children seem to be at a higher risk of developing CRS than adults.
Various studies estimated CRS in several hematologic malignancies, such as acute lymphoblastic B cell leukemia (B-ALL), chronic lymphocytic leukemia (CLL), and diffuse large B cell lymphoma (DLBCL) and myeloma with an estimated range of 70%, 80%, 90% and 50% respectively. (Maude et al., Neelapu et al., Turle et al., Ali et al.,)
Cytokine Release Syndrome Epidemiology
-
Delveinsight’s Cytokine Release Syndrome epidemiology division provides insights about historical and current patient pool and forecasted trends for every seven major countries.
-
The Cytokine Release Syndrome epidemiology data are studied through all possible divisions to give a better understanding of the Disease scenario in 7MM.
-
The Cytokine Release Syndrome epidemiology segment covers the epidemiology data in the US, EU5 countries (Germany, Spain, Italy, France, and the UK), and Japan from 2017 to 2030.
-
It also helps to recognize the causes of current and forecasted trends by exploring numerous studies, survey reports and views of key opinion leaders.
The incidence of CRS in patients receiving cancer immunotherapy varies widely depending on the type of immunotherapeutic agent. The onset of CRS can occur within a few days, and in the case of CAR T cell therapy, up to several weeks after infusion of the drug. With most conventional monoclonal antibodies, the incidence of CRS is relatively low, whereas T cell-engaging cancer immunotherapies carry a particularly high risk of CRS. (Vornhagen et al.)
Scope of the Report
-
The report provides insight into the historical and forecasted patient pool of Cytokine Release Syndrome in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK), and Japan.
-
The report assesses the disease risk and burden and highlights the unmet needs of Cytokine Release Syndrome.
-
The report helps to recognize the growth opportunities in the 7MM with respect to the patient population.
-
The Cytokine Release Syndrome report provides a detailed overview explaining Cytokine Release Syndrome causes, symptoms, classification, pathophysiology, diagnosis and treatment patterns.
-
The Cytokine Release Syndrome Epidemiology Report and Model provide an overview of the risk factors and global trends of Cytokine Release Syndrome in the seven major markets (7MM:US, France, Germany, Italy, Spain, UK, and Japan).
-
The report provides the segmentation of the Cytokine Release Syndrome epidemiology.
Key Benefit of Cytokine Release Syndrome Epidemiology Report
The Cytokine Release Syndrome Epidemiology report will allow the user to –
-
Develop business strategies by understanding the trends shaping and driving the global Cytokine Release Syndrome market
-
Quantify patient populations in the global Cytokine Release Syndrome market to improve product design, pricing, and launch plans
-
Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for Cytokine Release Syndrome therapeutics in each of the markets covered
-
Understand the magnitude of Cytokine Release Syndrome population by its epidemiology
-
The Cytokine Release Syndrome Epidemiology Model developed by DelveInsight is easy to navigate, interactive with dashboards, and epidemiology based with transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over 11-year forecast period using reputable sources
Table of Contents
-
Key Insights
-
Executive Summary of Cytokine Release Syndrome
-
Cytokine Release Syndrome Disease Background and Overview
-
Cytokine Release Syndrome Patient Journey
-
Cytokine Release Syndrome Epidemiology and Patient Population
-
Cytokine Release Syndrome Treatment Algorithm, Current Treatment, and Medical Practices
-
KOL Views on Cytokine Release Syndrome
-
Cytokine Release Syndrome Unmet Needs
-
Appendix
-
DelveInsight Capabilities
-
Disclaimer
*The table of contents is not exhaustive; will be provided in the final report
Related Reports
Cytokine Release Syndrome Market Insight, Epidemiology and Market Forecast – 2030
DelveInsight’s “Cytokine Release Syndrome – Market Insights, Epidemiology, and Market Forecast-2030” report delivers an in-depth understanding of the Cytokine Release Syndrome, historical and forecasted epidemiology as well as the Cytokine Release Syndrome market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.
About DelveInsight
DelveInsight is a leading Business Consultant, and Market Research Firm focused exclusively on life sciences. It supports pharma companies by providing end to end comprehensive solutions to improve their performance.
Get FREE sample copy at:
https://www.delveinsight.com/sample-request/cytokine-release-syndrome-epidemiology-forecast
Media Contact
Company Name: DelveInsight Business Research LLP
Contact Person: Anuj Rawat
Email: Send Email
Phone: +919650213330
Address:304 S. Jones Blvd #2432
City: Albany
State: New York
Country: United States
Website: https://www.delveinsight.com/