Creative Peptides, one of the global leading peptide suppliers, recently announced to reorganize its chelate peptides, a category added in last September to its already well-established supply list covering a wide variety of peptides such as antimicrobial peptides, cosmetic peptides, neoantigen peptide vaccine, cell-penetrating peptides and MHC peptides. All could be applied in both academic and industrial research.
Chelate peptides, alternatively referred to as DOTA or DOTA related peptides, are organic compounds widely employed as contrast agents for cancer treatments. When combined with other radioisotopes, chelate peptides can be employed in the diagnoses of cancer, as a result of its strong ability to link with molecules that have affinity to various structures.
Peptide-based targeting techniques are becoming increasingly popular for diagnostic and therapeutic applications. Compared with antibodies, they are advantageous for their more favorable pharmacokinetics and better tumor penetration. Peptide sequences that are capable of binding to their target with affinities comparable to those of monoclonal antibodies can be generated by chemical or phage display libraries.
“One major advantage of peptide tracers is their small size, allowing rapid distribution and clearance. Consequently, a peptide that is intended for use as a diagnostic or therapeutic tracer has to be used in the free form without the phage carrier protein,” explains the Product Manager at Creative Peptides. “Just to cite an example here on how chelate peptides work in medical disease diagnosis. In quite a number of studies, researchers have found somatostatin receptors on the cell surfaces of many neuroendocrine tumors. So if we could use a certain kind of peptide to bind with somatostatin receptors, like (Tyr3)-octreotate – a derivative of octreotide used in this case, then the detection of tumors is made possible.”
Overally speaking, depending on the metal ion, complexes of DOTA peptides have already been applied in the following three major fields: magnetic resonance imaging [GdIII), Eu(III)], nuclear imaging [111In(III), 68Ga(III), 64/67Cu(II)], and therapeutic radiopharmaceuticals [90Y(III), 177Lu(III)]. Various chelate peptides can be found at Creative Peptides.
For more information on chelate peptides like DOTA-(Tyr3)-Octreotate, please visit: https://www.creative-peptides.com/research-areas/chelate-peptides-dota-related-peptides.html.
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Aimed at creating a better and healthier world with concerted efforts from all industries, Creative Peptides keeps enriching its peptide related product and services in the last decade. From the year of 2018, Creative Peptides has directed more of its business focus from supplying a full range of peptides such as checkpoint inhibitors, therapeutic peptides, cosmetic peptides and catalog peptides to modification, synthesis, analysis services of peptides, such as Stapled Peptide Synthesis, Long Peptides Synthesis, Oligopeptide Synthesis, Post-translational Modification, Peptide Drug Discovery, Peptide Lead Optimization.
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