Creative Peptides Introduced Custom MHC-peptides Tetramer Service for Immunotherapy Trials

“MHC tetramer”
Creative Peptides announced to introduce custom MHC-peptides tetramer service for immunotherapy researchers on March 19, 2019.

As one of the world’s leading peptide suppliers, the New York-based company Creative Peptides announced to introduce custom MHC-peptides tetramer service for immunotherapy researchers on March 19, 2019, trying to speed up the industry’ efforts in exploring a cure for cancer. 

MHC-peptide tetramers are complexes consisting of four fluorophore-labeled major histocompatibility complex (MHC) molecules, with each individual monomer binding to a specific peptide respectively. Considering their structural uniqueness, MHC-peptide tetramers are useful tools for direct visualization or quantification of antigen-specific T cells. 

Since being first published in 1996 by a lab at Stanford University, MHC tetramer technology has drawn great attention from the research circle. As to why this technology is so important, Dr. Robert Martinez, Head of Creative Peptides’ synthesis businesses, explains in a recent statement, “This has something to do with how our immune system works. MHC molecules present peptides to T-cells as a way to inform them that viruses, bacteria, cancerous mutations, or other antigens have emerged in a cell. Let’s assume that a T cell receptor (TCR) happen to match the peptide being presented by an MHC molecule, then an immune response is triggered, which is the ideal case.”

Owing to the above-mentioned mechanism, MHC tetramers are bioengineered to present a specific peptide to find T-cells with receptors that match that peptide. According to the difference in binding with TCR, there are two types of tetramers: MHC Class I, which binds to a distinct population of CD8+ T cells; MHC Class II, which binds to a subset of CD4+ T cells.

“Via concerted efforts, MHC tetramer MHC tetramers have already been developed to assist HIV study as well as to investigate the effectiveness of vaccine delivery methods. Currently, two choices of fluorochrome labeling, phycoerythrin (PE) or allophycocyanin (APC), are available at Creative Peptides based on customer’s request,” says Dr. Robert. “We also provides clinical grade tetramer for clients to be used in immunotherapy trials.”

At present, the following MHC-peptide tetramers can be synthesized:

• Class I MHC tetramers for antigen-specific CD8+ T cells detection

• Class II MHC tetramers for antigen-specific CD4+ T cells detection ex vivo

• Human alleles

• Non-Human alleles

• Fluorophore-labeledtetramers for flow cytometry or fluorescence microscopy

• Negative tetramers as a negative control for Class I Tetramer staining

• CD1d tetramers for detection of natural killer T (NKT) cells 

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About Creative Peptides

From the year of 2018, Creative Peptides has redirected more its business focus from supplying a wide collection of peptides such as checkpoint inhibitors, therapeutic peptides, cosmetic peptides and catalog peptides to modification, synthesis, analysis services of peptides, such as Stapled Peptide Synthesis, Long Peptides Synthesis, Oligopeptide Synthesis, Peptide Drug Discovery, Peptide Lead Optimization.

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