How to ensure that live probiotics survive the harsh journey through the gastrointestinal tract and remain active precisely where they are needed has long been a shared challenge for both the research and industrial communities. Traditional probiotic formulations often suffer significant losses in viability due to gastric acid, bile salts, and digestive enzymes, compromising not only experimental reproducibility but also the potential for preclinical studies and product development.
The last few years have witnessed the quiet transformation of probiotic delivery technologies. Through strategies such as encapsulation, controlled release, and pH-responsiveness, these solutions create a safe passage for probiotics “from the lab bench to the target site.” Among them, microencapsulation stands out as a leading approach.
“In next-generation probiotic research—especially with oxygen-sensitive anaerobes—microencapsulation becomes particularly critical,” said the chief scientist of the microbial delivery platform at Creative Biolabs. “These strains are extremely sensitive to acid, oxygen, and digestive fluids. Without precise delivery, much of their research potential would be wasted.”
Modern microencapsulation goes beyond simple coating. By selecting specific natural or synthetic polymers, probiotics are embedded within a protective matrix and combined with multi-layer coatings and smart release mechanisms. This allows them to remain in a “dormant shielded” state under acidic gastric conditions, only gradually releasing once they reach the small intestine or colon. pH-responsive and colon-targeted drug delivery systems are direct extensions of this principle—leveraging the pH gradient along the gastrointestinal tract to trigger concentrated release in the colon (around pH 7.0), improving bioavailability and functional performance.
Creative Biolabs has been active in this field for years, integrating polymer science, microcapsule engineering, and microbiology to build a comprehensive platform tailored to diverse research needs. “We’re not selling a ‘fixed-recipe’ capsule,” the scientist added. “We offer a complete solution—from material selection, formulation optimization, and controlled release testing to performance validation. For anaerobic strains like Bacteroides or Faecalibacterium, for example, we factor in gas permeability, coating degradation mechanisms, and microbiota-triggered release into our design.”
The Creative Biolabs platform supports a wide range of manufacturing techniques, including spray drying, emulsion-based encapsulation, extrusion-gelation, electrospraying, and layer-by-layer coating. These are paired with gastric and intestinal fluid simulation tests, dynamic digestion models, CFU counting, flow cytometry, and scanning electron microscopy (SEM) imaging. This comprehensive toolkit enables research teams to quickly generate detailed data on viability, release kinetics, and structural stability—ensuring reproducible experimental conditions for academia and robust early-stage evaluation for new product development and regulatory submissions.
“Delivery technology is the ‘last mile’ of probiotic science,” the scientist concluded. “It is the critical step that determines both experimental success and product competitiveness. Through our platform, we hope to free researchers and developers from concerns over viability and targeting so they can focus on unlocking the true biological potential of probiotics.”
Company Overview
Creative Biolabs specializes in advanced biodelivery and formulation innovation, providing global research institutions and enterprises with end-to-end solutions—from formulation design and in vitro simulation to performance optimization.
Media Contact
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
City: Shirley
State: New York 11967
Country: United States
Website: https://live-biotherapeutic.creative-biolabs.com/