New York, January 17, 2019—Creative Biolabs, a custom service provider engaged in various antibody production and engineering fields, launches a comprehensive Computer-aided Platform for antibody development, named PreciAb™, which comprises a full set of technologies and proprietary algorithms for designing antibodies with defined formats and functions.
Antibodies refer to binding proteins produced by B lymphocytes to defend an organism against pathogens and foreign macromolecules, widely used as a research tool in diagnostics and also as therapeutic agents. Based on years of experience in computational structural biology and antibody engineering, the PreciAb™ platform has been established to develop high-quality and efficient antibodies through the following steps:
– Antibody structure construction through combining structure- and homology-based modeling methods
– Structure optimization by dynamics simulation, rotamer library, loop modeling, and etc.
– Complementarity-determining region (CDR) identification on the basis of tertiary structure of the antibody
– Antibody-antigen complex modeling and interaction analysis
– Paratope and epitope identification and key residues analysis
– Computer-aided antibody affinity maturation and function modification
– Global analysis and optimization of antibody biophysical properties (thermodynamic stability, aggregation propensity, immunogenicity)
“With the help of our PreciAb™ platform, we are confident to provide a range of epitope-specific antibody design services and antibody reformatting services with high specificity and affinity. In addition to computer-based analysis, we can offer knowledge-based analysis and advice on in silico antibody design for various downstream applications,” said the manager in Creative Biolabs.
Up to now, the major challenge in antibody modeling remains to be the prediction of the conformations of the CDR loops and modification of antibody affinity and function by computer-aided design coupled with knowledge-based design, scientists at Creative Biolabs will keep striving on improving the loop modeling techniques. For more information about the antibody custom service, please visit https://www.creative-biolabs.com/preciab/.
Creative Biolabs was founded by scientists who are dedicated to the conquering of cancer, believing that a custom-service-centered business model is important for optimizing the drug development process, leveraging accessible resources, and forming a team of various background to conduct drug discovery in future. The service portfolio includes mouse and rat monoclonal antibody production using hybridoma technology, human, monkey, rabbit, chicken, dog, llama and camel monoclonal antibody production using various antibody library technologies (including phage display, bacterial display and yeast display). In addition, OEM services for bulk scale antibody manufacturing, including bacterial production of scFv, diabody, tandem scFv, miniantibody and Fab, and mammalian cell expression of minibody, chimeric IgG and IgG, are also available at the most competitive price in the industry.
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Address:45-1 Ramsey Road
State: New York
Country: United States