DelveInsight’s “Coccidioidomycosis – Pipeline Insight, 2025” provides a comprehensive overview of the emerging treatment landscape for this neglected fungal disease caused by Coccidioides immitis and C. posadasii. While most cases are self-limiting, disseminated infections can be life-threatening and are often difficult to treat with currently approved azole antifungals such as fluconazole and itraconazole.
Recent efforts include NIH-supported vaccine initiatives and next-generation antifungals aimed at overcoming drug resistance and reducing treatment duration. A key pipeline highlight includes the Phase I/II development of NikZ (Nikkomycin Z) by Valley Fever Solutions, a chitin synthase inhibitor showing promise against both acute and chronic forms of the disease. Additionally, Scynexis’s second-generation antifungals (ibrexafungerp analogs) and Amplyx’s fosmanogepix have been explored in broader fungal programs and may extend toward endemic mycoses, including coccidioidomycosis.
Clinical trial activity remains moderate but focused, with the CDC and academic networks emphasizing improved diagnostics, antifungal stewardship, and clinical endpoints. Orphan drug designations and FDA QIDP (Qualified Infectious Disease Product) pathways are also being leveraged to expedite development timelines.
As 2025 progresses, the pipeline for Coccidioidomycosis reflects a growing urgency to address this underrecognized threat through targeted R&D, cross-institutional collaborations, and innovative therapeutic strategies poised to redefine care for at-risk populations in the southwestern U.S. and globally.
Interested in learning more about the current treatment landscape and the key drivers shaping the Coccidioidomycosis pipeline? Click here
Key Takeaways from the Coccidioidomycosis Pipeline Report
• DelveInsight’s Coccidioidomycosis pipeline analysis depicts a strong space with 3+ active players working to develop 3+ pipeline drugs for Coccidioidomycosis treatment.
• The leading Coccidioidomycosis companies include SCYNEXIS, Mycovia Pharmaceuticals, Amplyx Pharmaceuticals, F2G, and others are evaluating their lead assets to improve the Coccidioidomycosis treatment landscape.
• Key Coccidioidomycosis pipeline therapies in various stages of development include Ibrexafungerp, VT-1598, Fosmanogepix, F-901318, and others.
• As of June 18, 2025, Valley Fever Solutions confirmed that its inhalable Phase II-ready formulation of Nikkomycin Z (NikZ)—a chitin synthase inhibitor with potent activity against Coccidioides spp.—is entering trials aimed at curing early infection
• In June 2023, F2G announced that the FDA issued a Complete Response Letter (CRL) for olorofim’s New Drug Application, requesting additional data before approval. The company is continuing global Phase III “OASIS” trials comparing olorofim to standard-of-care treatments, targeting invasive fungal diseases including coccidioidomycosis.
Request a sample and discover the recent breakthroughs happening in the Coccidioidomycosis pipeline landscape.
Coccidioidomycosis Overview
Coccidioidomycosis, also known as Valley Fever, is a fungal infection caused by Coccidioides species—primarily Coccidioides immitis and Coccidioides posadasii. These fungi are found in soil in arid regions, particularly in the southwestern United States, parts of Mexico, and Central and South America. Infection typically occurs when fungal spores are inhaled into the lungs.
Symptoms range from mild flu-like illness to severe pneumonia, and in rare cases, the infection can spread beyond the lungs to other parts of the body, including the skin, bones, and central nervous system. While many people recover without treatment, antifungal medications such as fluconazole or itraconazole are used in moderate to severe cases. People with weakened immune systems are at higher risk for complications. Early diagnosis and treatment are important for managing more serious infections.
Find out more about Coccidioidomycosis medication at https://www.delveinsight.com/report-store/coccidioidomycosis-pipeline-insight
Coccidioidomycosis Treatment Analysis: Drug Profile
Ibrexafungerp: SCYNEXIS
Ibrexafungerp (formerly SCY-078) is a first-in-class triterpenoid and a novel glucan synthase inhibitor. It exhibits broad antifungal activity against Candida, including multidrug-resistant strains like Candida auris, as well as Aspergillus and Pneumocystis. Available in both oral and IV formulations, it offers treatment flexibility for both inpatient and outpatient settings.
VT-1598: Mycovia Pharmaceuticals
VT-1598 is an investigational oral antifungal currently in Phase 1 development by Mycovia Pharmaceuticals. It targets serious fungal infections, particularly those with rising multidrug resistance. The drug has received QIDP designation, Fast Track status, and Orphan Drug designation for Valley fever (coccidioidomycosis), with cryptococcal meningitis also qualifying for the FDA’s priority review voucher program.
Coccidioidomycosis Therapeutics Assessment
By Product Type
• Mono
• Combination
• Mono/Combination.
By Stage
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
By Route of Administration
• Inhalation
• Inhalation/Intravenous/Oral
• Intranasal
• Intravenous
• Intravenous/ Subcutaneous
• NA
• Oral
• Oral/intranasal/subcutaneous
• Parenteral
• Subcutaneous
By Molecule Type
• Antibody
• Antisense oligonucleotides
• Immunotherapy
• Monoclonal antibody
• Peptides
• Protein
• Recombinant protein
• Small molecule
• Stem Cell
• Vaccine
Scope of the Coccidioidomycosis Pipeline Report
• Coverage: Global
• Key Coccidioidomycosis Companies: SCYNEXIS, Mycovia Pharmaceuticals, Amplyx Pharmaceuticals, F2G, and others.
• Key Coccidioidomycosis Pipeline Therapies: Ibrexafungerp, VT-1598, Fosmanogepix, F-901318, and others.
Explore detailed insights on drugs used in the treatment of Coccidioidomycosis here.
Table of Contents
1. Introduction
2. Executive Summary
3. Coccidioidomycosis Pipeline: Overview
4. Analytical Perspective In-depth Commercial Assessment
5. Coccidioidomycosis Pipeline Therapeutics
6. Coccidioidomycosis Pipeline: Late-Stage Products (Phase III)
7. Coccidioidomycosis Pipeline: Mid-Stage Products (Phase II)
8. Coccidioidomycosis Pipeline: Early Stage Products (Phase I)
9. Therapeutic Assessment
10. Inactive Products
11. Company-University Collaborations (Licensing/Partnering) Analysis
12. Key Companies
13. Key Products
14. Unmet Needs
15. Market Drivers and Barriers
16. Future Perspectives and Conclusion
17. Analyst Views
18. Appendix
About DelveInsight
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform, PharmDelve.
Media Contact
Company Name: DelveInsight
Contact Person: Jatin Vimal
Email: Send Email
Phone: +14699457679
Address:304 S. Jones Blvd #2432
City: Las Vegas
State: Nevada
Country: United States
Website: https://www.delveinsight.com/