DelveInsight’s “Chronic Rhinosinusitis Market Insights, Epidemiology, and Market Forecast 2032” report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the Chronic Rhinosinusitis market size, share, trends, and growth opportunities in the seven major markets (7MM) (i.e., the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom and Japan).
The report covers emerging Chronic Rhinosinusitis drugs, current treatment practices, market share of individual therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current Chronic Rhinosinusitis treatment practice/algorithm, key drivers & barriers impacting the market growth, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.
Chronic Rhinosinusitis: An Overview
Chronic Rhinosinusitis (CRS) is an inflammatory condition of the paranasal sinuses that most often causes chronic sinonasal symptoms. It is a disease of inflammation of the nose and paranasal sinuses and upper airways characterized by 12 weeks of persistent symptoms, including congestion, stuffiness, nasal discharge, pain or facial pressure, impairment or loss of the sense of smell (anosmia), cough, and fatigue.
Chronic Rhinosinusitis (CRS) can be classified according to the presence of a nasal polyp (NP): CRS with NP (CRSwNP) and CRS without NP (CRSsNP). CRSwNP has characteristics with high infiltration of tissue eosinophilia with a burst of Th2 inflammatory cytokine. CRSwNP can be further classified into eosinophilic and noneosinophilic. According to a study by Elisabeth et al., CRS is approximately twice as common in females as compared to males.
Chronic Rhinosinusitis Market Key Facts
The study by Sedaghat et al., titled “Chronic Rhinosinusitis”, estimates that chronic rhinosinusitis is an inflammatory disease of the paranasal sinuses with a prevalence of 1–5% in the United States.
According to the Royal College of Surgeons, Chronic Rhinosinusitis is a highly prevalent condition affecting 10% of the UK adult population.
According to Stevens et al., CRSwNP is estimated to occur in seven percent of all asthmatics while asthma is reported in 26–48% of patients with CRSwNP. Furthermore, CRSwNP is a disease of middle age, with the average age of onset being 42 years and the typical age of diagnosis ranging from 40 years to 60 years.
The market outlook section of the report helps to build a detailed comprehension of the historical, current, and forecasted market size by analyzing the impact of current and emerging Chronic Rhinosinusitis pipeline therapies. It also thoroughly assesses the Chronic Rhinosinusitis market drivers & barriers, unmet needs, and emerging technologies set to impact the market dynamics.
The report gives complete details of the market trend for each marketed Chronic Rhinosinusitis drug and mid & late-stage pipeline therapies by evaluating their impact based on the annual cost of therapy, their Mechanism of Action (MOA), Route of Administration (ROA), molecule types, competition with other therapies, brand value, and their impact on the market.
Chronic Rhinosinusitis Epidemiology Assessment
The epidemiology section provides insights into the historical, current, and forecasted Chronic Rhinosinusitis epidemiology trends in the seven major countries (7MM) from 2019 to 2032. It helps to recognize the causes of current and forecasted Chronic Rhinosinusitis epidemiology trends by exploring numerous studies and research. The epidemiology section also provides a detailed analysis of diagnosed and prevalent patient pools, future trends, and views of key opinion leaders.
The Report Covers the Chronic Rhinosinusitis Epidemiology, Segmented as –
Total Prevalent Cases of Chronic Rhinosinusitis (CRS) in the 7MM (2019–2032)
Gender-Specific Prevalent Cases of CRS in the 7MM (2019–2032)
Type-Specific Prevalent Cases of CRS (CRSwNP and CRSsNP) in the 7MM (2019–2032)
Diagnosed and Treatable Cases of CRS in the 7MM (2019–2032)
Chronic Rhinosinusitis Drugs Uptake and Pipeline Development Activities
The drug uptake section focuses on the uptake rate of potential drugs recently launched in the Chronic Rhinosinusitis market or expected to be launched during the study period. The analysis covers the Chronic Rhinosinusitis market uptake by drugs, patient uptake by therapies, and sales of each drug. Moreover, the therapeutics assessment section helps understand the market dynamics by drug sales, the most rapid drug uptake, and the reasons behind the maximal use of particular drugs. Additionally, it compares the Chronic Rhinosinusitis drugs based on their sale and market share.
The report also covers the Chronic Rhinosinusitis pipeline development activities. It provides valuable insights about different therapeutic candidates in various stages and the key Chronic Rhinosinusitis companies involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.
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Chronic Rhinosinusitis Therapeutics Analysis
There are no definitive guidelines for the treatment of Chronic Rhinosinusitis, largely due to the lack of consensus on the etiology of the disease. Chronic Rhinosinusitis has commonly been treated with courses of oral antibiotics, but the lack of clinical evidence for their efficacy in Chronic Rhinosinusitis makes this therapy controversial unless the patient is suffering from a superimposed acute bacterial inflammation upon the underlying chronic inflammatory condition.
Several major pharma and biotech companies are developing therapies for Chronic Rhinosinusitis. Currently, Lyra Therapeutics is leading the therapeutics market with its Chronic Rhinosinusitis drug candidates in the most advanced stage of clinical development.
On April 25, 2023, Lyra Therapeutics announced that it has resumed screening and enrollment in ENLIGHTEN II, its second pivotal Phase 3 clinical trial of LYR-210 in patients with CRS. LYR-210 is a bioresorbable nasal implant designed as an alternative to sinus surgery for the millions of CRS patients who remain symptomatic despite treatment.
Chronic Rhinosinusitis Companies Actively Working in the Therapeutics Market Include
Keymed Biosciences Co.Ltd
Kyowa Kirin Co., Ltd.
Sanotize Research and Development Corp.
And many others
Emerging and Marketed Chronic Rhinosinusitis Therapies Covered in the Report Include:
CBP-201: Connect Biopharma
Dupixent (dupilumab): Sanofi
GB001: Gossamer Bio
LYR-210: Lyra Therapeutics
Xolair (omalizumab): Genentech
And many more
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Table of Content (TOC)
1. Key Insights
2. Executive Summary
3. Chronic Rhinosinusitis Competitive Intelligence Analysis
4. Chronic Rhinosinusitis Market Overview at a Glance
5. Chronic Rhinosinusitis Disease Background and Overview
6. Chronic Rhinosinusitis Patient Journey
7. Chronic Rhinosinusitis Patient Population and Epidemiology Trends (In the US, EU5, and Japan)
8. Chronic Rhinosinusitis Treatment Algorithm, Current Treatment, and Medical Practices
9. Chronic Rhinosinusitis Unmet Needs
10. Key Endpoints of Chronic Rhinosinusitis Treatment
11. Chronic Rhinosinusitis Marketed Therapies
12. Chronic Rhinosinusitis Emerging Drugs and Latest Therapeutic Advances
13. Chronic Rhinosinusitis Seven Major Market Analysis
14. Attribute Analysis
15. Chronic Rhinosinusitis Market Outlook (In US, EU5, and Japan)
16. Chronic Rhinosinusitis Companies Active in the Market
17. Chronic Rhinosinusitis Access and Reimbursement Overview
18. KOL Views on the Chronic Rhinosinusitis Market
19. Chronic Rhinosinusitis Market Drivers
20. Chronic Rhinosinusitis Market Barriers
22. DelveInsight Capabilities
*The Table of Contents (TOC) is not exhaustive; the final content may vary. Refer to the sample report for the complete table of contents.
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