“Chronic Lymphocytic Leukemia Pipeline Insight, 2024“ report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the Chronic Lymphocytic Leukemia Market.

The Chronic Lymphocytic Leukemia Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. The report also covers a detailed description of the drug, including the mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, collaborations, mergers acquisition, funding, designations, and other product-related details.

Some of the key takeaways from the Chronic Lymphocytic Leukemia Pipeline Report:

• Companies across the globe are diligently working toward developing novel Chronic Lymphocytic Leukemia treatment therapies with a considerable amount of success over the years.

• Chronic Lymphocytic Leukemia companies working in the treatment market are Bristol Myers Squibb, AbbVie/Johnson & Johnson, Merck Sharp & Dohme, Ascentage Pharma, Sana Biotechnology, Novartis Pharmaceuticals, Janssen Research & Development, LLC, NovalGen Ltd, Genmab, Ascentage Pharma Group Inc., Loxo Oncology, Oncternal Therapeutics, MingSight Pharmaceuticals, Nurix Therapeutics, and others, are developing therapies for the Chronic Lymphocytic Leukemia treatment

• Emerging Chronic Lymphocytic Leukemia therapies in the different phases of clinical trials are- BREYANZI, IMBRUVICA, Nemtabrutinib, Lisaftoclax (APG-2575), SG 299, JBH492, JNJ-64264681, NVG-111, Epcoritamab, APG2575, Pirtobrutinib, Cirmtuzumab, MS-553, NX-2127, NX-5948, and others are expected to have a significant impact on the Chronic Lymphocytic Leukemia market in the coming years.

• In December 2024, Eli Lilly and Company (NYSE: LLY) has announced results from the Phase 3 BRUIN CLL-321 trial evaluating pirtobrutinib, a reversible (non-covalent) Bruton’s tyrosine kinase (BTK) inhibitor, in adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) previously treated with a covalent BTK inhibitor. The trial met its primary endpoint of progression-free survival (PFS) during the primary analysis, showing that pirtobrutinib outperformed the investigator’s choice of idelalisib plus rituximab (IdelaR) or bendamustine plus rituximab (BR), as assessed by an independent review committee (IRC). The final prespecified analysis confirmed sustained PFS improvement with pirtobrutinib, reducing the risk of relapse, disease progression, or death by 46% compared to IdelaR or BR.

• In December 2024, Genmab A/S (Nasdaq: GMAB) has released findings from the Phase 1b/2 EPCORE® CLL-1 clinical trial, which evaluated epcoritamab, a subcutaneously administered T-cell-engaging bispecific antibody (Abstract #883). The trial showed an overall response rate (ORR) of 61% and a complete response (CR) rate of 39% in adult patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) treated with epcoritamab monotherapy.

• In December 2024, Nurix Therapeutics, Inc. (Nasdaq: NRIX), a clinical-stage biopharmaceutical company focused on developing targeted protein modulation therapies for cancer and inflammatory diseases, has unveiled promising clinical data from its Phase 1a/1b trial. The study evaluated the Bruton’s tyrosine kinase (BTK) degrader NX-5948 in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).

• In July 2024, AstraZeneca, a UK-based pharmaceutical company, has announced positive results from the Phase III AMPLIFY clinical trial evaluating Calquence (acalabrutinib) for the treatment of chronic lymphocytic leukemia (CLL). This global, multi-center, open-label trial assessed the efficacy and safety of a fixed-duration regimen of Calquence in previously untreated adult patients with CLL. The treatment plan included Calquence in combination with venetoclax, with the optional addition of obinutuzumab.

Chronic Lymphocytic Leukemia Overview

The blood malignancy chronic lymphocytic leukaemia (CLL) is one such instance. It is the most prevalent type of adult leukaemia. When healthy white blood cells (lymphocytes) in your bone marrow convert into malignant cells, they proliferate and force out platelets and good blood cells.

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Emerging Chronic Lymphocytic Leukemia Drugs Under Different Phases of Clinical Development Include:

• BREYANZI: Bristol Myers Squibb

• IMBRUVICA: AbbVie/Johnson & Johnson

• Nemtabrutinib: Merck Sharp & Dohme

• Lisaftoclax (APG-2575): Ascentage Pharma

• SG 299: Sana Biotechnology

• JBH492: Novartis Pharmaceuticals

• JNJ-64264681: Janssen Research & Development, LLC

• NVG-111: NovalGen Ltd

• Epcoritamab: Genmab

• APG2575: Ascentage Pharma Group Inc.

• Pirtobrutinib : Loxo Oncology

• Cirmtuzumab: Oncternal Therapeutics

• MS-553: MingSight Pharmaceuticals

• NX-2127: Nurix Therapeutics

• NX-5948: Nurix Therapeutics

Chronic Lymphocytic Leukemia Route of Administration

Chronic Lymphocytic Leukemia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs, such as

• Oral

• Parenteral

• Intravenous

• Subcutaneous

• Topical

Chronic Lymphocytic Leukemia Molecule Type

Chronic Lymphocytic Leukemia Products have been categorized under various Molecule types, such as

• Monoclonal Antibody

• Peptides

• Polymer

• Small molecule

• Gene therapy

Chronic Lymphocytic Leukemia Pipeline Therapeutics Assessment

• Chronic Lymphocytic Leukemia Assessment by Product Type

• Chronic Lymphocytic Leukemia By Stage and Product Type

• Chronic Lymphocytic Leukemia Assessment by Route of Administration

• Chronic Lymphocytic Leukemia By Stage and Route of Administration

• Chronic Lymphocytic Leukemia Assessment by Molecule Type

• Chronic Lymphocytic Leukemia by Stage and Molecule Type

DelveInsight’s Chronic Lymphocytic Leukemia Report covers around 60+ products under different phases of clinical development like

• Late-stage products (Phase III)

• Mid-stage products (Phase II)

• Early-stage product (Phase I)

• Pre-clinical and Discovery stage candidates

• Discontinued & Inactive candidates

• Route of Administration

Further Chronic Lymphocytic Leukemia product details are provided in the report. Download the Chronic Lymphocytic Leukemia pipeline report to learn more about the emerging Chronic Lymphocytic Leukemia therapies

Some of the key companies in the Chronic Lymphocytic Leukemia Therapeutics Market include:

Key companies developing therapies for Chronic Lymphocytic Leukemia are – F. Hoffmann-La Roche Ltd, AstraZeneca, Secura Bio, Inc, Novartis AG, AbbVie, Inc., Gilead Sciences, Inc., BeiGene, Inc., Sanofi (Genzyme Corporation), Ziopharm Oncology Inc, Ono pharmaceuticals Co Ltd, Teva Pharmaceutical Industries, and others.

Chronic Lymphocytic Leukemia Pipeline Analysis:

The Chronic Lymphocytic Leukemia pipeline report provides insights into

• The report provides detailed insights about companies that are developing therapies for the treatment of Chronic Lymphocytic Leukemia with aggregate therapies developed by each company for the same.

• It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Chronic Lymphocytic Leukemia Treatment.

• Chronic Lymphocytic Leukemia key companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.

• Chronic Lymphocytic Leukemia Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.

• Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Chronic Lymphocytic Leukemia market.

The report is built using data and information traced from the researcher’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations, and featured press releases from company/university websites and industry-specific third-party sources, etc.

Download Sample PDF Report to know more about Chronic Lymphocytic Leukemia drugs and therapies

Chronic Lymphocytic Leukemia Pipeline Market Drivers

• Rise in Global Prevalence of Chronic Lymphocytic Leukemia Coupled With the Increasing Geriatric Population, huge Product Pipeline along with Growing Research Activities are some of the important factors that are fueling the Chronic Lymphocytic Leukemia Market.

Chronic Lymphocytic Leukemia Pipeline Market Barriers

• However, higher Cost of the Patented Drugs and Therapies, side Effects Associated with Chemotherapy and other factors are creating obstacles in the Chronic Lymphocytic Leukemia Market growth.

Scope of Chronic Lymphocytic Leukemia Pipeline Drug Insight

• Coverage: Global

• Key Chronic Lymphocytic Leukemia Companies: Bristol Myers Squibb, AbbVie/Johnson & Johnson, Merck Sharp & Dohme, Ascentage Pharma, Sana Biotechnology, Novartis, Janssen Research & Development, LLC, NovalGen Ltd, Genmab, Ascentage Pharma Group Inc., Loxo Oncology, Oncternal Therapeutics, MingSight Pharmaceuticals, Nurix Therapeutics, and others

• Key Chronic Lymphocytic Leukemia Therapies: BREYANZI, IMBRUVICA, Nemtabrutinib, Lisaftoclax (APG-2575), SG 299, JBH492, JNJ-64264681, NVG-111, Epcoritamab, APG2575, Pirtobrutinib, Cirmtuzumab, MS-553, NX-2127, NX-5948, and others

• Chronic Lymphocytic Leukemia Therapeutic Assessment: Chronic Lymphocytic Leukemia current marketed and Chronic Lymphocytic Leukemia emerging therapies

• Chronic Lymphocytic Leukemia Market Dynamics: Chronic Lymphocytic Leukemia market drivers and Chronic Lymphocytic Leukemia market barriers

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Table of Contents

1. Chronic Lymphocytic Leukemia Report Introduction

2. Chronic Lymphocytic Leukemia Executive Summary

3. Chronic Lymphocytic Leukemia Overview

4. Chronic Lymphocytic Leukemia- Analytical Perspective In-depth Commercial Assessment

5. Chronic Lymphocytic Leukemia Pipeline Therapeutics

6. Chronic Lymphocytic Leukemia Late Stage Products (Phase II/III)

7. Chronic Lymphocytic Leukemia Mid Stage Products (Phase II)

8. Chronic Lymphocytic Leukemia Early Stage Products (Phase I)

9. Chronic Lymphocytic Leukemia Preclinical Stage Products

10. Chronic Lymphocytic Leukemia Therapeutics Assessment

11. Chronic Lymphocytic Leukemia Inactive Products

12. Company-University Collaborations (Licensing/Partnering) Analysis

13. Chronic Lymphocytic Leukemia Key Companies

14. Chronic Lymphocytic Leukemia Key Products

15. Chronic Lymphocytic Leukemia Unmet Needs

16 . Chronic Lymphocytic Leukemia Market Drivers and Barriers

17. Chronic Lymphocytic Leukemia Future Perspectives and Conclusion

18. Chronic Lymphocytic Leukemia Analyst Views

19. Appendix

20. About DelveInsight

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate business growth and overcome challenges with a practical approach.

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