An electrochemical biosensor is an integrated device capable of providing accurate analytical information that may be quantitative or semi-quantitative, by using a biochemical receptor, which is a biological recognition element that retains direct spatial contact with an electrochemical transduction element. The combination of electrochemistry biomedical sensors and microfluidics is an emerging application in cell culture monitoring market. These are further integrated together with each other to extract better results in various domains of cell culture, tissue engineering, and regenerative medicine.
Biosensors made by combination of microfluidic and electrochemistry are particularly useful for integration of cell culture with analysis and extraction of valuable insights. For instance, voltammetric and amperometric biosensors have been incorporated into microfluidic systems for H2O2 generation by cellular activities using HRP. In 2014, according to Hindawi Publishing Corporation and BioMed Research International, the thermometric, magnetic, and piezoelectric transducers were not exert a practical impact in the applications of tissue engineering and regenerative medicine. The gradual success of optical-fiber sensors is attributed to their application in tackling difficult measurement situations where conventional sensors do not provide the required accuracy.
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Furthermore, these sensors are usually compact, lightweight with effectively multiplexed on a single fiber network along being with minimally invasive. Electromagnetic interference do not affect the results, as they do not have electrical current flowing at the sensing point, which could interfere with the reading. Fiber optic biosensors can also survive in difficult environments and are compatible with wide range of physical situations such as high doses of radiation, which favors its market revenue growth in the nuclear medicine industry.
Cell culture finds applications for research and product development across a wide range of sectors, including food, pharmaceuticals, and biotechnology, among others. Cell culture technique allows for quick manufacturing of vaccines and biotechnology products. The growing biosimilars industry, is further expected to increase demand for cell culture monitoring for biosensors. Growing preference for personalized medicines is also fueling growth of the cell culture monitoring biosensors market, as culture technique is used for identifying potential biomarkers and developing a targeted drug therapy with accurate and continuous monitoring of critical cell culture parameters at regular time intervals. These factors are expected to fuel the demand for cell culture monitoring biosensors during the forecast period. Devices need to ensure accuracy and security of data generated. For this, sensors in the devices need to be very sensitive to changes in the cell size, count, temperature, and other parameters. Furthermore, demand for portable devices in turn is fuelling demand for micro- and nano-sized sensors with high sensitivity and accuracy.
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The growing cell culture application in research and product development, Application of cell culture is quite significant and pronounced in every research and product development in the food, pharmaceutical, biotechnology, and other sectors. Cell culture technique has enabled quick manufacturing of vaccines and biotechnology products. Moreover, a spike in growth is expected in the biosimilars market which will further propel the demand for cell culture monitoring and hence, the need for biosensors. Personalized medicines is the new trend in the market. Cell culture technique used for identifying potential biomarkers and develop a targeted drug therapy requires accurate and continuous monitoring of critical cell culture parameters at regular time interval. All these factors are expected to fuel the demand for cell culture monitoring biosensors during the forecast period
Manual monitoring of cell culture involves risk of contamination, threat to cell culture viability, and involves the arduous task of regular monitoring by research personnel. Automated cell culture monitoring using the biosensors effectively addresses all these concerns. This is expected to be a major driving factor for cell culture monitoring biosensors market. Using biosensors, researcher can prevent contamination, reduce monitoring errors, and decrease cell culture variability. Moreover, frequent manual intervention also decreases. Electrochemical and optical biosensors enables detecting microscopic changes, hydrogen peroxide levels, glucose levels, and many such parameters. Further, increasing research on piezoelectric biosensors will propel the cell culture monitoring biosensors market.
C-CIT Sensors AG, Sarissa Biomedical Ltd., Lonza, Lifeonics, Nova Biomedical and Conductive Technologies, Inc., are some of the key players in the market. Lifeonics has developed a cell culture monitoring device that can be placed in the cell culture flask till the time one wants to monitor the culture. The devices is chargeable and can be reused in another cell culture monitoring process. Such innovative devices will also benefit and boost the cell culture monitoring biosensors market.
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