DelveInsight’s, “CAR T – Cell Therapy Competitive landscape, 2025,” report provides comprehensive insights about 250+ companies and 500+ drugs in CAR T – Cell Therapy Competitive landscape. It covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

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Key Takeaways from the CAR-T Cell Therapy Competitive Landscape Report

• On 20 August 2025, Juno Therapeutics Inc. announced a study is to compare the efficacy and safety of arlo-cel (BMS-986393) versus standard regimens in adult participants with Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma.
• On 19 August 2025, Novartis Pharmaceuticals conducted a study is to monitor all patients exposed to CAR-T therapied for 15 years following their last CAR-T (e.g. CTL019) infusion to assess the risk of delayed adverse events (AEs), monitor for replication competent lentivirus (RCL) and assess long-term efficacy, including vector persistence.
• DelveInsight’s CAR-T Cell Therapy competitive landscape report depicts a robust space with 250+ active players working to develop 500+ pipeline therapies for CAR-T Cell Therapy treatment.
• The leading CAR-T Cell Therapy Companies such as Cartesian Therapeutics, CASI Pharmaceuticals, Juventas Cell Therapy, Novartis, Poseida Therapeutics, Shanghai Unicar-Therapy Bio-medicine Technology, JW Therapeutics, Gilead Sciences, Cellular Biomedicine Group, Gracell Bio, Mustang Bio, Servier, iCell Gene Therapeutics, Kecellitics Biotech Company Ltd, Gilead Sciences, Miltenyi Biotec, Nanjing KAEDI Biotech, Liminatus Pharma, Yake Biotechnology, AffyImmune Therapeutics, Fundamenta Therapeutics, Actinium Pharmaceuticals, Allogene Therapeutics, Celyad Oncology, Maxcyte, Sorrento Therapeutics, Cellular Biomedicine Group, Sorrento Therapeutics, Shanghai GeneChem Co., Ltd., Sensei Biotherapeutics, Obsidian Therapeutics, Beijing Biohealthcare Biotechnology Co. Ltd., Eutilex/Utilities, Precigen, Inc., Miltenyi Biomedicine, Wugen, WindMIL Therapeutics, MiNK Therapeutics, CiMaas, Catamaran Bio, Innate Pharma, Healios, Chimeric Therapeutics, ONK Therapeutics, Neukio Biotherapeutics, Exacis Biotherapeutics, Editas Medicine and others.
• Promising CAR-T Cell Therapy Therapies such as Itacitinib, Cyclophosphamide, Fludarabine, CD7 CAR-T, Cevostamab, JNJ-68284528, Lenalidomide, Daratumumab, KYV-101 and others.

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CAR T-Cell Therapy Marketed Therapies

• JW Therapeutics

JW Therapeutics is an innovative biotechnology company focusing on developing, manufacturing and commercializing cell immunotherapy products. Co-founded by Juno Therapeutics (a Bristol Myers Squibb company) and WuXi AppTec in 2016, JW Therapeutics is committed to becoming an innovation leader in cell immunotherapy. The company has built a top world-class platform for technology and product development in cell immunotherapy, as well as a promising product pipeline covering both hematologic malignancies and solid tumors, to bring the hope of a cure for Chinese and global patients, and to lead the healthy and standardized development of China’s cell immunotherapy industry.

• Relmacabtagene autoleucel

Relmacabtagene autoleucel injection (abbreviated as Relma-cel, trade name: Carteyva®) is an autologous anti-CD19 CAR-T cell immunotherapy product independently developed by JW Therapeutics based on a CAR-T cell process platform of Juno Therapeutics (a Bristol Myers Squibb company). Being the first product of JW Therapeutics, Relma-cel was approved by the China National Medical Products Administration (NMPA) in September 2021 for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, making it the first CAR-T product approved as Category 1 biologics product in China. Currently, it is the only CAR-T product in China that has been simultaneously included in the National Significant New Drug Development Program, granted priority review and breakthrough therapy designations. Relma-cel is the first CAR-T product approved as a Category 1 biologics product in China, and sixth approved CAR-T product globally. Relma-cel, JW Therapeutics’ first CAR-T product, was independently developed based on a CAR T cell process platform of Juno Therapeutics (a Bristol Myers Squibb company) to meet the needs of the Chinese market.

• Kite Pharma

Kite, a Gilead Company, is a global biopharmaceutical company based in Santa Monica, California, with manufacturing operations in North America and Europe. Kite’s singular focus is cell therapy to treat and potentially cure cancer. As the cell therapy leader, Kite has more approved CAR T indications to help more patients than any other company. The goal is to fundamentally change the way people think about cancer treatment by pushing the boundaries of what is possible with cell therapy — using genetically modified immune cells to target tumors. Its industry-leading cell therapy technology uses the power of a person’s own immune system to target and attack their tumors. This is accomplished through the use of genetically modified T cells that can increase the number of tumor-specific T cells and strengthen the body’s ability to kill certain types of cancer cells.

• KTE-X19

KTE-X19 is an investigational, autologous, anti-CD19 CAR T cell therapy. KTE-X19 uses the XLP™ manufacturing process that includes T-cell selection and lymphocyte enrichment. Lymphocyte enrichment is a necessary step in certain B-cell malignancies with evidence of circulating lymphoblasts. KTE-X19 is currently in Phase I/II trials in acute lymphoblastic leukemia (ALL), mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL).In December 2020, Kite, announced that the European Commission has granted conditional marketing authorization for Tecartus (autologous, anti-CD19-transduced CD3+ cells; formerly KTE-X19). Tecartus is a chimeric antigen receptor (CAR) T cell therapy for adult patients with relapsed or refractory mantle cell lymphoma after two or more lines of systemic therapy including a Bruton’s tyrosine kinase (BTK) inhibitor. In July 2020, the U.S. Food and Drug Administration (FDA) has granted accelerated approval to Tecartus (brexucabtagene autoleucel, formerly KTE-X19), the first and only approved chimeric antigen receptor (CAR) T cell therapy for the treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL).

• Bristol Myers Squibb

Bristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. Celgene and Juno Therapeutics are wholly owned subsidiaries of Bristol-Myers Squibb Company. In certain countries outside the U.S., due to local laws, Celgene and Juno Therapeutics are referred to as, Celgene, a Bristol Myers Squibb company and Juno Therapeutics, a Bristol Myers Squibb company. Bristol Myers Squibb is inspired by a single vision—transforming patients’ lives through science. The goal of the company’s cancer research is to deliver medicines that offer each patient a better, healthier life and to make cure a possibility.

• Abecma

Abecma recognizes and binds to BCMA on the surface of multiple myeloma cells leading to CAR T cell proliferation, cytokine secretion, and subsequent cytolytic killing of BCMA-expressing cells. Abecma is being jointly developed and commercialized in the U.S. as part of a Co-Development, Co-Promotion, and Profit Share Agreement between Bristol Myers Squibb and 2seventy bio. The companies’ broad clinical development program for Abecma includes clinical studies (KarMMa-2, KarMMa-3, KarMMa-9) in earlier lines of treatment for patients with multiple myeloma. Abecma is the first and only CAR T cell therapy approved that is directed to recognize and bind to BCMA, a protein that is nearly universally expressed on cancer cells in multiple myeloma, leading to the death of BCMA-expressing cells.

CAR T- Cell Pipeline Therapies and Companies

• CARsgen

CARsgen is a biopharmaceutical company with operations in China and the US and is focused on innovative CAR T-cell therapies for the treatment of hematologic malignancies and solid tumors. The Company has built an integrated cell therapy platform with in-house capabilities that span target discovery, antibody development, clinical trials, and commercial-scale manufacturing. CARsgen has internally developed novel technologies and a product pipeline with global rights to address major challenges of CAR T-cell therapies, such as improving the safety profile, enhancing the efficacy in treating solid tumors and reducing treatment costs. The Company’s vision is to become a global biopharmaceutical leader that brings innovative and differentiated cell therapies to cancer patients worldwide and makes cancer curable.

• Zevorcabtagene autoleucel

Zevor-cel (CT053) is a fully human, autologous BCMA CAR T-cell product candidate for the treatment of R/R MM. CT053 uses a CAR construct with a fully human BCMA-specific single-chain variable fragment designed to have lower immunogenicity and increased stability. CARsgen is conducting a Phase I/II clinical trial to evaluate the safety and efficacy of zevor-cel for R/R Multiple myeloma. The Company also plans to conduct additional clinical trials to develop zevor-cel as an earlier line of treatment for multiple myeloma. CARsgen hopes the therapy will address challenges of T-cell exhaustion by reducing self-activation of CAR T-cells when tumor-associated targets are not present. The Company believes that zevor-cel is well positioned to potentially reshape the treatment paradigm for multiple myeloma and become a foundational treatment for multiple myeloma patients.

• Cartesian Therapeutics

Founded in 2016 and with three assets currently in clinical trials, Cartesian is the leader in mRNA-engineered cell therapy. Cartesian’s vision is to cure disease by mRNA engineering any cell, to deliver to any tissue, any combination of therapies. The company is pioneering mRNA cell therapies in and beyond oncology, with products in development for respiratory, autoimmune, and oncologic disorders. All investigational therapies are manufactured at Cartesian’s wholly owned, state-of-the-art cGMP manufacturing facility in Gaithersburg, MD.

• Descartes 011

Descartes-11 is engineered with Cartesian’s RNA Armory℠ platform to express its CAR molecules transiently instead of permanently, thereby reducing both short-term and long-term risks inherent with conventional CAR T-cell therapies. Descartes-11 is manufactured in-house at Cartesian’s wholly owned, state-of-the-art cGMP manufacturing facility in Gaithersburg, MD. A Phase 1 study of Descartes-11 in patients with advanced myeloma showed no evidence of typical CAR T-cell toxicities such as cytokine release syndrome (CRS) of neurotoxicity. Tens of billions of cells are mRNA-engineered with the CAR molecule so that the full therapeutic dose can be administered with each infusion. This eliminates the need for preconditioning chemotherapy required by conventional CAR T-cell therapies. Currently the drug is in Phase II stage of Clinical trial evaluation for the treatment of Multiple Myeloma.

• Autolus Therapeutics plc.

Autolus is a clinical-stage biopharmaceutical company developing next-generation, programmed T cell therapies for the treatment of cancer. Using a broad suite of proprietary and modular T cell programming technologies, the Company is engineering precisely targeted, controlled and highly active T cell therapies that are designed to better recognize cancer cells, break down their defense mechanisms and eliminate these cells. Autolus has a pipeline of product candidates in development for the treatment of hematological malignancies and solid tumors.

• AUTO8

AUTO8 is our next-generation product candidate for multiple myeloma which comprises two independent CARs for the multiple myeloma targets, BCMA and CD19. Company have developed an optimized BCMA CAR which is designed for improved killing of target cell that express BCMA at low levels. This has been combined with fast off rate CD19 CAR from obe-cel. Autolus Therapeutics believe that the design of AUTO8 has the potential to induce deep and durable responses and extend the durability of effect over other BCMA CARs currently in development.

• Sana Biotechnology

Sana Biotechnology, Inc. is focused on creating and delivering engineered cells as medicines for patients. We share a vision of repairing and controlling genes, replacing missing or damaged cells, and making our therapies broadly available to patients. We are a passionate group of people working together to create an enduring company that changes how the world treats disease. Sana has operations in Seattle, Cambridge, South San Francisco, and Rochester.

• SG299

SG299 has the potential to generate CAR T cells in vivo (inside the patient), eliminating the need for conditioning chemotherapy and complex CAR T cell manufacturing. The company’s goal is to file an IND this year to study this drug candidate in patients with B cell malignancies. In 2022, Sana transitioned to a new manufacturing process for SG295 and renamed the product SG299 in connection with that transition. SG299 has at least a 50X improvement in product potency, which Sana believes has the potential to translate into better efficacy, safety, and long-term manufacturability. The company plans to use this second-generation process for the first-in-human studies in patients with B cell malignancies.

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CAR T – Cell Therapy Analytical Perspective by DelveInsight

In-depth Commercial Assessment: CAR T – Cell Therapy Collaboration Analysis by Companies

The Report provides in-depth commercial assessment of drugs that have been included, which comprises collaboration, agreement, licensing and acquisition – deals values trends. The sub-segmentation is described in the report which provide company-company collaboration (licensing/partnering), company academic collaboration and acquisition analysis in tabulated form.

CAR T – Cell Therapy Competitive Landscape

The report comprises of comparative assessment of Companies (by therapy, development stage, and technology).

CAR T- Cell Therapy Report Assessment

• CAR T-Cell Therapy Company Analysis
• CAR T-Cell Therapy Therapeutic Assessment
• CAR T- Cell Therapy Pipeline Assessment
• CAR T-Cell Therapy Inactive drugs assessment
• CAR T-Cell Therapy Unmet Needs

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Scope of the CAR-T Cell Therapy Pipeline Report

• Coverage- Global
• CAR-T Cell Therapy Companies- Cartesian Therapeutics, CASI Pharmaceuticals, Juventas Cell Therapy, Novartis, Poseida Therapeutics, Shanghai Unicar-Therapy Bio-medicine Technology, JW Therapeutics, Gilead Sciences, Cellular Biomedicine Group, Gracell Bio, Mustang Bio, Servier, iCell Gene Therapeutics, Kecellitics Biotech Company Ltd, Gilead Sciences, Miltenyi Biotec, Nanjing KAEDI Biotech, Liminatus Pharma, Yake Biotechnology, AffyImmune Therapeutics, Fundamenta Therapeutics, Actinium Pharmaceuticals, Allogene Therapeutics, Celyad Oncology, Maxcyte, Sorrento Therapeutics, Cellular Biomedicine Group, Sorrento Therapeutics, Shanghai GeneChem Co., Ltd., Sensei Biotherapeutics, Obsidian Therapeutics, Beijing Biohealthcare Biotechnology Co. Ltd., Eutilex/Utilities, Precigen, Inc., Miltenyi Biomedicine, Wugen, WindMIL Therapeutics, MiNK Therapeutics, CiMaas, Catamaran Bio, Innate Pharma, Healios, Chimeric Therapeutics, ONK Therapeutics, Neukio Biotherapeutics, Exacis Biotherapeutics, Editas Medicine and others.
• CAR-T Cell Therapy Therapies- Itacitinib, Cyclophosphamide, Fludarabine, CD7 CAR-T, Cevostamab, JNJ-68284528, Lenalidomide, Daratumumab, KYV-101 and others.
• CAR-T Cell Therapy Marketed Therapies and Pipeline Therapies
• CAR-T Cell Therapy Preclinical and Discovery Stage Products, Unmet Needs

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Table of Contents

1. Introduction
2. Executive Summary
3. CAR T – Cell Therapy: Overview
4. CAR T – Cell Therapy-Analytical Perspective: In-depth Commercial Assessment
5. Competitive Landscape
6. Therapeutic Assessment
7. CAR T – Cell Therapy: Company and Product Profiles (Marketed Therapies)
8. JW Therapeutics
9. Relmacabtagene autoleucel
10. Oncolytic Virus Cancer Therapy: Company and Product Profiles (Pipeline Therapies)
11. Late Stage Products (Registered)
12. CARsgen
13. Zevorcabtagene autoleucel
14. Drug profiles in the detailed report…..
15. Mid Stage Products (Phase II)
16. Cartesian Therapeutics
17. Descartes 011
18. Drug profiles in the detailed report…..
19. Early Stage Products (Phase I)
20. Autolus Therapeutics
21. AUTO-8
22. Drug profiles in the detailed report…..
23. Preclinical and Discovery Stage Products
24. Sana Biotechnology
25. SG299
26. Drug profiles in the detailed report…..
27. Inactive Products
28. CAR T – Cell Therapy – Unmet needs
29. CAR T – Cell Therapy– Market drivers and barriers
30. Appendix

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