The Ankylosing Spondylitis market report provides an edge while developing business strategies, by understanding trends shaping and driving the global Ankylosing Spondylitis market. A detailed review of the historical and forecasted Ankylosing Spondylitis market is included in the report, covering drug outreach in the 7MM.
Ankylosing Spondylitis Overview
Ankylosing Spondylitis (AS) also called Bechterew’s disease is a common inflammatory rheumatic disease that affects the axial skeleton, causing characteristic inflammatory back pain, which can lead to structural and functional impairments and a decrease in quality of life. Clinical features of this group include inflammatory back pain, asymmetrical peripheral oligoarthritis (predominantly of the lower limbs), enthesitis, and specific organ involvement such as anterior uveitis, psoriasis, and chronic inflammatory bowel disease. Aortic root involvement and conduction abnormalities are rare complications of AS. AS affects men more often than women.
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Some of the key highlights of the Ankylosing Spondylitis Market Report
- DelveInsight’s estimates suggest that there were 1,389,116 prevalent cases of AS in 2017 in the 7MM, and these prevalent cases are expected to increase further during the study period, 2017–2030.
- As per DelveInsight’s assessments, the United States accounted for the highest prevalent population of Ankylosing Spondylitis, followed by EU5 and Japan.
- AS is typically diagnosed in people younger than 40 years, and about 80% of patients develop first symptoms when they were younger than 30 years. Less than 5% of patients present when they are older than 45 years (Wenker et al., 2019).
- According to the review of literature, the total prevalence of SpA in Germany is approximately 1–1.4% and the prevalence of AS is estimated to be 0.5% (Braun et al., 2019).
Ankylosing Spondylitis Epidemiology Segmentation
- Total Prevalent Cases
- Gender Specific Prevalent Cases
- Diagnosed Cases
- Severity-Specific Prevalent Cases
Ankylosing Spondylitis Treatment Market
Ankylosing Spondylitistreatment goals are alleviation of pain, recovery of physical functions related to daily life, occupational activities, and delay of structural damage responsible for physical impairments. The most important component of non-drug treatments of Ankylosing spondylitis (AS) is the education of patients and regular exercise.
Ankylosing Spondylitis Market Outlook
At present, the therapeutic market size of AS is mainly accounted for by physical therapy, surgery, non-steroidal anti-inflammatory drugs (NSAIDs: ibuprofen, and naproxen), steroids (corticosteroids), disease-modifying anti-rheumatic drugs (DMARDs: methotrexate), and biologics.
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Ankylosing Spondylitis Diagnosis
The most commonly used criteria for the classification of AS were developed in 1966 and modified in 1984. They are:
1. Low back pain of at least three months duration with inflammatory characteristics (improved by exercise, not relieved by rest)
2. Limitation of lumbar spine motion in sagittal and frontal planes
3. Decreased chest expansion (relative to normal values for age and sex)
4. Bilateral sacroiliitis grade 2 or higher
5. Unilateral sacroiliitis grade 3 or higher.
Ankylosing Spondylitis Treatment
Treatment of Ankylosing spondylitis will depend on the symptoms, age, and general health. It will also depend on how severe the condition is. The treatment goal is to reduce pain and stiffness, prevent deformities, and maintain as normal lifestyle as possible. Treatment may include: Nonsteroidal anti-inflammatory medications to reduce pain and inflammation, tumor-necrosis-factor blockers (biologic medications) to reduce inflammation and swelling, disease-modifying antirheumatic drugs (DMARDs) such as sulfasalazine to decrease inflammation and control AS, short-term use of corticosteroids to reduce inflammation, short-term use of muscle relaxants and pain relievers to relieve severe pain and muscle spasms, surgery to replace a joint, place rods in the spine, or remove parts of the thickened and hardened bone. Moreover, maintaining proper posture and regular exercise, including exercises that strengthen back muscles, is vital (Johns Hopkins Medicine, n.d.)
Ankylosing Spondylitis Emerging Drugs
- Tofacitinib: Pfizer
- Bimekizumab: UCB Biopharma
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Ankylosing Spondylitis Companies
- UCB Inc.
- AbbVie
- Pfizer
- Amgen/Pfizer
- Janssen Biotech
- Pozen
- Novartis
- Merck
- Iroko Pharmaceuticals
- Biogen, and others
Ankylosing Spondylitis Drugs
- Benepali
- Indocin
- Arcoxia
- Cosentyx
- Vimovo
- Simponi
- Remicade
- Enbrel
- Celebrex
- Humira
- Cimzia, and others
Table of content
1. Key Insights
2. Executive Summary
3. Disease Background and Overview
4. Case Reports
5. Patient Journey
6. Epidemiology and Patient Population
7. Current Treatment and Medical Practices
8. Unmet needs
9. Marketed drugs
10. Emerging Therapies
12. Potential of Emerging Therapies and Current therapies
13. Attribute Analysis
14. Key Market Forecast Assumptions
15. Market Methodology
16. Ankylosing Spondylitis (AS): United States Market Outlook
17. Market Drivers
18. Market Barriers
19. SWOT Analysis
20. Reimbursement and Market access
21. Appendix
22. DelveInsight Capabilities
23. Disclaimer
24. About DelveInsight
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