Achondroplasia is the most common of skeletal dysplasia that results in marked short stature (dwarfism). It is a human bone genetic disorder of the growth plate and is the most common form of inherited disproportionate short stature.
DelveInsight’s “Achondroplasia Market Insights, Epidemiology, and Market Forecast-2030″ report delivers an in-depth understanding of the Achondroplasia, historical and forecasted epidemiology as well as the Achondroplasia market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.
Some facts of Achondroplasia Market Report are:
- According to Columbia University Medical Center (CUMC), this disorder occurs in approximately 1 in 25,000 live births worldwide.
- The prevelance rates have correlation to father’s age as mutations occur exclusively in the male and older men who have a higher probability of having an affected child than younger ones (Deepali N.shinde et al)
- The population-based study conducted by DK.Waller et al in US, stated that the prevalence of de novo Achondroplasia has been significantly increased with age of father. The prevelance data varied according to father’s age such as 25–29, 30–34, 35–39, and ≥40 years, with reported rates of 2.8, 2.8, 4.9 and 5.0 respectively.
- The prevalence of achondroplasia ranged from 0.36 to 0.60 per 10,000 livebirths
- According to a study, the recurrence risk of Achondroplasia among siblings of an affected individual was found to be 0.23% (Mettler and Fraser)
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Scope of the Achondroplasia Market Report
- The report covers the descriptive overview of Achondroplasia, explaining its causes, signs and symptoms, pathophysiology, diagnosis and currently available therapies
- Comprehensive insight has been provided into the Achondroplasia epidemiology and treatment in the 7MM
- Additionally, an all-inclusive account of both the current and emerging therapies for Achondroplasia are provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape
- A detailed review of Achondroplasia market; historical and forecasted is included in the report, covering drug outreach in the 7MM
- The report provides an edge while developing business strategies, by understanding trends shaping and driving the global Achondroplasia market
List of Achondroplasia Key Players involved in the report
- BioMarin
- Ascendis Pharma
- Therachon
- Pfizer
- And many others
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Achondroplasia Market Report
The children affected by Achondroplasia are delayed in reaching gross motor milestones such as head control, and independent sitting and walking. There are some serious neurological problems that may also occur due to narrowing of the spinal canal and nerve compression.
Achondroplasia Market Insights
It is caused by one of two mutations (G1138A and G1138C) in the FGFR3 (Fibroblast Growth Factor Receptor 3) gene at chromosome locus 4p16.3. The mutations cause the FGFR3 protein to be overly active, which interferes with skeletal development and leads to disturbances in bone growth seen with this disorder.
- Vosoritide
- TA-46
- TransCon CNP
- Infigratinib (Bridgebio/Qued)
- And Many others
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Achondroplasia Treatment Market
The current market is occupied with this symptomatic treatment and surgery only. To be effective, a new treatment approach must consider Achondroplasia is a complex disease, correcting the short stature and preventing complications. Understanding the pathophysiology of the disease is essential to achieve this and correcting the growth of all bones affected by the disease, will define the future treatment strategy.
Table of Content:
1. Key Insights
2. Executive Summary of Achondroplasia
3. Competitive Intelligence Analysis for Achondroplasia
4. Achondroplasia: Market Overview at a Glance
4.1. Achondroplasia Total Market Share (%) Distribution in 2018
4.2. Achondroplasia Total Market Share (%) Distribution in 2030
5. Achondroplasia: Disease Background and Overview
6. Patient Journey
7. Achondroplasia Epidemiology and Patient Population
8. Treatment Algorithm, Current Treatment, and Medical Practices
9. Unmet Needs
10. Key Endpoints of Achondroplasia Treatment
11. Marketed Products
List to be continued in report
12. Emerging Therapies
List to be continued in report
13. Achondroplasia: Seven Major Market Analysis
14. Attribute analysis
15. 7MM: Market Outlook
16. Access and Reimbursement Overview of Achondroplasia
17. KOL Views
18. Market Drivers
19. Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
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