New York, US – October 23, 2018 – As a supplier-of-choice for scientists engaged in bispecific antibody field across the globe, Creative Biolabs is all the time dedicated to collecting hot therapeutic targets and providing a variety of customized bispecific antibody (BsAb) products.
Based on the advanced strategies, different formats of BsAb products can be developed to adapt the valency, structure, half-life and biodistribution, etc., including Tandem Fab, CrossMab, Tandem scFv, IgG-scFv, Diabody, IgG-IgG, Triple Body, Fab-IgG, TandAb, Single-chain Diabody, Single-chain Triplebody, which fit the desired the target-product profile.
Tandem Fab, a class of Fab-based bispecific antibody fragments, comprises two Fabs targeting different epitopes. With a higher thermally stability than the corresponding scFv, Fab is usually expressed as a 3-chain construct and has a His-tag for affinity purification. The two Fd regions are connected by a flexible linker. Tandem Fab is bispecific and has monovalent for each antigen specificity (1+1 antigen-binding valency).
CrossMab is a type of IgG-like bispecific antibody that remains the general structure and size of a conventional IgG. In CrossMAb, KIH (knobs-into-holes) technology is used to permit the heavy chain heterodimerize. Light chain mispairing is overcome by antibody domain crossovers, entire Fab domain crossover, merely variable domains or constant domains crossover. The crossover can keep the antigen-binding capacity of the parental antibody. Usually, the referred CrossMab is a bispecific, bivalent molecule, 1+1 antigen-binding valency, with similar biophysical properties to IgGs. Multivalent and bispecific molecules can be generated by using the versatile CrossMab technology.
Equipped with the latest technologies and state of the art platforms, Creative Biolabs is capable of offering a wide range of customized bispecific antibodies that cover all you need. In addition, Creative Biolabs also offers customized BsAb design services either for scientific research or clinical practice at the early stage of BsAb development.
About Creative Biolabs
Creative Biolabs was established in 2004 by scientists who are dedicated to conquering of cancer. Over the past 10 years, Creative Biolabs has grown into a recognized world leader in antibody (rAb) discovery, engineering, production, and analysis. Standing on the shoulder of a giant, the bispecific antibody (BsAb) team has a collective of experienced scientists committed to providing high-quality services to customers all over the world. Now, with the cutting-edge platforms and methods (quadroma development, chemical conjugation, and genetic engineering), a comprehensive list of bispecific antibody products is available to customers in academia and industry fields.
Company Name: Creative Biolabs
Contact Person: Bella Smith
Email: Send Email
Address:45-1 Ramsey Road
State: New York
Country: United States