DelveInsight’s report, “Osteoarthritis Market Insights, Epidemiology, and Market Forecast-2034,” provides a comprehensive analysis of the Osteoarthritis landscape. The report delivers detailed insights into the disease, including historical and projected epidemiology, helping stakeholders understand the prevalence, incidence, and patient demographics across key regions.

Additionally, it examines Osteoarthritis market dynamics, offering a thorough assessment of current and emerging market trends, treatment patterns, and therapeutic developments. The analysis spans major markets, including the United States, EU4 (Germany, Spain, Italy, France, and the United Kingdom), and Japan, equipping decision-makers with actionable intelligence for strategic planning, investment, and research initiatives.

To Know in detail about the Osteoarthritis market outlook, drug uptake, treatment scenario and epidemiology trends, Click here; Osteoarthritis Market Forecast

Some of the key facts of the Osteoarthritis Market Report:

• In 2023, the Osteoarthritis market size was the largest in the United States among the 7MM, valued at around USD 19,000 million, and is projected to grow further by 2034 at a CAGR of 3%.

• In 2023, opioids accounted for the largest share of the Osteoarthritis treatment market by therapy class in the United States, generating approximately USD 9,200 million.

• In February 2026, OrthoTrophix Inc., a privately held company focused on developing innovative investigational treatments for Osteoarthritis, has announced the ahead-of-schedule completion of patient enrollment in its Phase 2b clinical trial. The study is assessing intra-articular TPX-100 for Knee osteoarthritis. This multicenter trial in the United States began in May 2025 and is anticipated to conclude in the first quarter of 2027.

• In January 2026, 4Moving Biotech (4MB), a clinical-stage biotechnology company focused on developing next-generation, disease-modifying therapies for osteoarthritis (OA), announced that the U.S. Food and Drug Administration (FDA) has approved its Investigational New Drug (IND) application for 4P004. This clearance allows the Phase 2a INFLAM MOTION clinical trial to expand into the United States. The FDA approval represents a strategic milestone in 4MB’s global clinical efforts across Europe, Canada, and now the U.S., strengthening the company’s position as a leader in the pursuit of the first disease-modifying osteoarthritis drug (DMOAD) for patients worldwide.

• In November 2025, Novo Nordisk has released new findings from the OASIS 4 Phase 3 trial, which investigated various patient populations and hypotheses, further supporting the potential of this therapy. Injectable semaglutide 2.4 mg, marketed as Wegovy®, is approved in the EU as an adjunct to a reduced-calorie diet and increased physical activity for weight management in adults with a BMI of ≥30 kg/m² (obesity) or ≥27 kg/m² (overweight) with at least one weight-related comorbidity. Wegovy® is also approved for pediatric patients aged 12 and older with an initial BMI at or above the 95th percentile and body weight over 60 kg. The label highlights clinical evidence of major adverse cardiovascular event (MACE) risk reduction, improvements in HFpEF-related symptoms and physical function, and pain relief for knee osteoarthritis.

• In May 2025, Lipogems announced the successful completion of its ARISE I U.S. FDA IDE Study, with the final patient visit now concluded. This marks a significant milestone in progressing Lipogems as a treatment option for knee osteoarthritis (OA) in patients who are not eligible for or ready to undergo knee replacement. The double-blind, randomized controlled trial included 173 participants across 18 leading U.S. clinical sites. The study’s primary focus is on assessing pain relief and functional improvement 12 months after injection. Results on efficacy and safety are anticipated by late 2025.

• In May 2025, Genascence Corporation, a clinical-stage biotech firm focused on transforming musculoskeletal disease treatment through gene therapy, reported positive 12-month safety and biomarker findings from its Phase 1b DONATELLO trial of GNSC-001. This investigational gene therapy targets interleukin 1 (IL-1) for treating knee osteoarthritis (OA). The 12-month results confirmed the trial met its primary endpoint, showing consistent safety and tolerability across all tested doses. Additionally, the study met a key secondary endpoint, demonstrating sustained IL-1Ra expression in synovial fluid, reinforcing the six-month data previously reported.

• In May 2025, Moximed, a pioneering medical device company focused on enhancing care for individuals with knee osteoarthritis (OA), announced that the first patients have been treated in its latest randomized controlled trial (RCT). The MOTION study is a prospective, multicenter trial designed to compare the effectiveness of the MISHA Knee System against non-surgical treatment options in patients with medial knee osteoarthritis.

• In April 2025, Pacira BioSciences reported that its gene therapy candidate, PCRX-201 (enekinragene inzadenovec), showed long-lasting improvements in knee pain, mobility, and stiffness for up to two years in a Phase I trial. Participants received a single local injection of the therapy. The study included 72 individuals aged 30 to 80, categorized based on the severity of their knee osteoarthritis using the Kellgren-Lawrence (K/L) grading system.

• In April 2025, Israel-based Enlivex Therapeutics announced the completion of enrollment for the Phase II portion of its Phase I/II trial evaluating Allocetra, an off-the-shelf cell therapy for moderate to severe knee osteoarthritis. In this phase, over 133 subjects were randomized and treated. The multi-center, randomized trial is divided into two stages, with Phase I being an open-label, dose-escalation study focused on assessing the safety and tolerability of Allocetra injections into the knee.

• In March 2025, RION, a clinical-stage company specializing in regenerative medicine and exosome-based therapies, announced the enrollment of the first patient in its Phase 1b trial of Purified Exosome Product™ (PEP™) for treating Osteoarthritis (OA). This marks a significant step in RION’s mission to develop cutting-edge regenerative solutions for unmet medical needs.

• In September 2024, Cytonics announced the completion of patient enrollment in a Phase I clinical trial for CYT-108, which is being investigated as a potential disease-modifying therapy for knee osteoarthritis (OA). CYT-108 is a recombinant variant of the alpha-2-macroglobulin blood serum protease inhibitor.

• The total number of Osteoarthritis Diagnosed Cases in the US rise from 2020-2034. In 2023, there were approximately 38,600,000 cases of Osteoarthritis in the US. As per the analysis, a higher percentage of mild cases of Osteoarthritis was observed in the US, followed by moderate Osteoarthritis in 2023.

• Amongst EU4 and the UK, in 2023, the highest proportion of Osteoarthritis age-specific cases were observed in 70 years and above, followed by age group of 60-69 years and 50-59 years.

• As per the analysis, the highest percentage of gender-specific distribution of Osteoarthritis was observed among female population than the male population in 2023. About 24,300,000 cases of Osteoarthritis in the US were contributed by female population.

• In Japan, there were around 8,600,000 cases of mild osteoarthritis in 2023, which are projected to increase during the study period.

• Key Osteoarthritis Companies: Merck KGaA, Peptinov, LG Chem, Akan Bioscience, BioTissue,Inc., Eupraxia Pharmaceuticals Inc., OliPass Corporation, Bone Therapeutics, Techfields Pharma, Biosplice Therapeutics, and others

• Key Osteoarthritis Therapies: M6495, PPV 06, LG00034053, StroMel, TTAX03, EP-104IAR, OLP 1002, JTA-004, X 0002, Lorecivivint, and others

• The Osteoarthritis market is expected to surge due to the disease’s increasing prevalence and awareness during the forecast period. Furthermore, launching various multiple-stage Osteoarthritis pipeline products will significantly revolutionize the Osteoarthritis market dynamics.

Osteoarthritis Overview

Osteoarthritis is the most common form of arthritis, characterized by the gradual breakdown of cartilage the protective tissue at the ends of bones. As the cartilage wears down, bones begin to rub against each other, leading to pain, stiffness, swelling, and reduced joint mobility.

It most commonly affects weight-bearing joints such as the knees, hips, and spine, as well as the hands. Osteoarthritis is strongly associated with aging, but other risk factors include obesity, joint injuries, genetics, and repetitive stress on joints.

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Osteoarthritis Epidemiology

The epidemiology section provides insights into the historical, current, and forecasted epidemiology trends in the seven major countries (7MM) from 2020 to 2034. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. The epidemiology section also provides a detailed analysis of the diagnosed patient pool and future trends.

Osteoarthritis Epidemiology Segmentation:

The Osteoarthritis market report proffers epidemiological analysis for the study period 2020–2034 in the 7MM segmented into:

• Osteoarthritis Prevalent population

• Osteoarthritis Joint site-specific distribution

• Osteoarthritis Gender-specific distribution

• Osteoarthritis Age-specific distribution

• Osteoarthritis Severity-specific prevalence

Download the report to understand which factors are driving Osteoarthritis epidemiology trends @ Osteoarthritis Epidemiology Forecast

Osteoarthritis Drugs Uptake and Pipeline Development Activities

The drugs uptake section focuses on the rate of uptake of the potential drugs recently launched in the Osteoarthritis market or expected to get launched during the study period. The analysis covers Osteoarthritis market uptake by drugs, patient uptake by therapies, and sales of each drug.

Moreover, the therapeutics assessment section helps understand the drugs with the most rapid uptake and the reasons behind the maximal use of the drugs. Additionally, it compares the drugs based on market share.

The report also covers the Osteoarthritis Pipeline Development Activities. It provides valuable insights about different therapeutic candidates in various stages and the key companies involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.

Osteoarthritis Therapies and Key Companies

• ZILRETTA: Flexion Therapeutics/Pacira BioSciences

• CINGAL: Anika Therapeutics

• TRIVISC: OrthogenRx / Avanos Medical

• VISCO-3: Zimmer Biomet/Seikagaku Corporation

• LNA043: Novartis

• ReNu (Amniotic Suspension Allograft): Organogenesis

• CNTX-4975: Centrexion Therapeutics

• JTA-004: BioSenic (Bone Therapeutics)

• M6495: Merck KGaA

• PPV 06: Peptinov

• LG00034053: LG Chem

• StroMel: Akan Bioscience

• TTAX03: BioTissue,Inc.

• EP-104IAR: Eupraxia Pharmaceuticals Inc.

• OLP 1002: OliPass Corporation

• JTA-004: Bone Therapeutics

• X 0002: Techfields Pharma

• Lorecivivint: Biosplice Therapeutics

Discover more about therapies set to grab major Osteoarthritis market share @ Osteoarthritis Treatment Landscape

Osteoarthritis Market Drivers

• Rising global prevalence driven by aging populations and increasing life expectancy

• Growing incidence of obesity and sedentary lifestyles, key risk factors for osteoarthritis

• Increasing awareness and early diagnosis of joint disorders

• Advancements in pain management therapies, including NSAIDs, biologics, and regenerative approaches

• Expanding pipeline of disease-modifying osteoarthritis drugs (DMOADs)

• Technological progress in joint replacement surgeries and minimally invasive procedures

• Increased healthcare spending and improved access to orthopedic care

• Growing adoption of combination therapies (pharmacological + physical therapy)

Osteoarthritis Market Barriers

• Lack of curative or disease-modifying treatments, with most therapies focused on symptom relief

• High cost associated with advanced treatments and joint replacement surgeries

• Side effects linked to long-term use of NSAIDs and pain medications

• Stringent regulatory requirements for approval of novel therapies (especially DMOADs)

• Heterogeneous disease progression, making clinical trial design complex

• Limited awareness and delayed diagnosis in low- and middle-income regions

• Reimbursement challenges for newer and high-cost interventions

• Patient reluctance toward surgical procedures due to risks and recovery time

Scope of the Osteoarthritis Market Report

• Study Period: 2020–2034

• Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan]

• Key Osteoarthritis Companies: Merck KGaA, Peptinov, LG Chem, Akan Bioscience, BioTissue,Inc., Eupraxia Pharmaceuticals Inc., OliPass Corporation, Bone Therapeutics, Techfields Pharma, Biosplice Therapeutics, and others

• Key Osteoarthritis Therapies: M6495, PPV 06, LG00034053, StroMel, TTAX03, EP-104IAR, OLP 1002, JTA-004, X 0002, Lorecivivint, and others

• Osteoarthritis Therapeutic Assessment: Osteoarthritis current marketed and Osteoarthritis emerging therapies

• Osteoarthritis Market Dynamics: Osteoarthritis market drivers and Osteoarthritis market barriers

• Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter’s five forces, BCG Matrix, Market entry strategies

• Osteoarthritis Unmet Needs, KOL’s views, Analyst’s views, Osteoarthritis Market Access and Reimbursement

To know more about Osteoarthritis companies working in the treatment market, visit @ Osteoarthritis Clinical Trials and Therapeutic Assessment

Table of Contents

1. Osteoarthritis Market Report Introduction

2. Executive Summary for Osteoarthritis

3. SWOT analysis of Osteoarthritis

4. Osteoarthritis Patient Share (%) Overview at a Glance

5. Osteoarthritis Market Overview at a Glance

6. Osteoarthritis Disease Background and Overview

7. Osteoarthritis Epidemiology and Patient Population

8. Country-Specific Patient Population of Osteoarthritis

9. Osteoarthritis Current Treatment and Medical Practices

10. Osteoarthritis Unmet Needs

11. Osteoarthritis Emerging Therapies

12. Osteoarthritis Market Outlook

13. Country-Wise Osteoarthritis Market Analysis (2020–2034)

14. Osteoarthritis Market Access and Reimbursement of Therapies

15. Osteoarthritis Market Drivers

16. Osteoarthritis Market Barriers

17. Osteoarthritis Appendix

18. Osteoarthritis Report Methodology

19. DelveInsight Capabilities

20. Disclaimer

21. About DelveInsight

About DelveInsight

DelveInsight is a leading Healthcare Business Consultant, and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate the business growth and overcome challenges with a practical approach.

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