Ovarian Cancer (OC) is the 5th most common tumor in women and also the most widespread gynecological cancer.
The rates of ovarian cancer are high in some major developed regions, being specifically high in the Northern Europe region, according to Cancer Research, UK, 2008. Major advancements in the treatment of ovarian cancer have been done in the last few years through the introduction of platinum-based compounds, as well as improvements in surgical procedures.
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The global market for ovarian cancer therapeutics is dominated by the usage of generics-predominately carboplatin & paclitaxel that are used together in the treatment of platinum-sensitive ailments (both first line as well as recurrent). The global ovarian cancer therapeutics market is expected to grow at a CAGR of 3.3% to USD 1.8 billion during the forecast period (from 2014 to 2020).
Early treatments with platinum-based therapy are generally effective, with almost 60 to 70% of cases entering remission. However, on the other hand, even with an extended Progression Free Survival (PFS) of one year, almost all cases relapse; and after some successive remission & relapse periods, they either die or develop platinum-resistant ailment, for which the diagnosis is poor. There is an obvious gap in the global market for maintenance therapies to expand the early huge rates of remission, as well as a gap for extra efficient therapy choices in refractory or platinum-resistant patients.
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The existing developmental pipeline notices such gaps in the global market. However, effectiveness with late-stage therapeutics has been poor, at best representing nominal developments in PFS. In the Europe region, both the drugs i.e., Yondelis and Avastin are approved based on the improvements in PFS. Thus, it is expected that the pipeline drugs that exhibited the major developments in PFS, such as Vynfinit, olaparib, & trebananib, will get approved in the region. But, on the other hand, the lack of great improvements in medical benefits with these drugs, as well as their estimated higher prices are said to limit their demand or sales.
In the US, the observed PFS improvements with Avastin & Yondelis, in the absence of other medical benefits with either drug, caused disapprovals of these drugs. As a result, the market is projected to be mainly driven by inflation & an increase in the occurrences of pancreatic cancer.
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