{"id":795291,"date":"2026-03-11T19:44:02","date_gmt":"2026-03-11T19:44:02","guid":{"rendered":"https:\/\/www.abnewswire.com\/pressreleases\/?p=795291"},"modified":"2026-03-11T19:44:02","modified_gmt":"2026-03-11T19:44:02","slug":"chronic-myeloid-leukemia-clinical-trial-pipeline-appears-robust-with-20-key-pharma-companies-actively-working-in-the-domain-delveinsight-kartos-therapeutics-aop-orphan-pharmaceuticals","status":"publish","type":"post","link":"https:\/\/www.abnewswire.com\/pressreleases\/chronic-myeloid-leukemia-clinical-trial-pipeline-appears-robust-with-20-key-pharma-companies-actively-working-in-the-domain-delveinsight-kartos-therapeutics-aop-orphan-pharmaceuticals_795291.html","title":{"rendered":"Chronic Myeloid Leukemia Clinical Trial Pipeline Appears Robust With 20+ Key Pharma Companies Actively Working in the Domain | DelveInsight | Kartos Therapeutics, AOP Orphan Pharmaceuticals"},"content":{"rendered":"<div style=\"float:right; width:250px; padding:8px 10px 10px 10px;\">\n<div><a href=\"https:\/\/www.abnewswire.com\/upload\/2026\/03\/1773251707.jpg\" style=\"border:none !important;\" target=\"_blank\" rel=\"nofollow\" ><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-29\" title=\"Chronic Myeloid Leukemia Clinical Trial Pipeline Appears Robust With 20+ Key Pharma Companies Actively Working in the Domain | DelveInsight | Kartos Therapeutics, AOP Orphan Pharmaceuticals\" src=\"https:\/\/www.abnewswire.com\/upload\/2026\/03\/1773251707.jpg\" alt=\"Chronic Myeloid Leukemia Clinical Trial Pipeline Appears Robust With 20+ Key Pharma Companies Actively Working in the Domain | DelveInsight | Kartos Therapeutics, AOP Orphan Pharmaceuticals\" width=\"225\" height=\"225\" style=\"padding:0px 0px 10px 10px; border:0 solid !important;\" \/><\/a><\/div>\n<div class=\"quotes\">\n<div>Chronic Myeloid Leukaemia \u2013 Pipeline Insight, 2026<\/div>\n<\/div>\n<\/div>\n<div style=\"font-style:italic; padding:8px 0px;\">DelveInsight&#8217;s latest report provides comprehensive insights about 20+ companies, including Kartos Therapeutics, AOP Orphan Pharmaceuticals, Biokine Therapeutics, Incyte Corporation, Sana Biotechnology, Novartis, Nerviano Medical Sciences, Sun Pharma Advanced Research Company and others, developing several pipeline drugs in the Chronic Myeloid Leukemia (CML) pipeline landscape.<\/div>\n<p style=\"text-align: justify;\">DelveInsight&#8217;s &ldquo;Chronic Myeloid Leukaemia &ndash; Pipeline Insight, 2026&rdquo; report provides comprehensive insights about 20+ companies developing several pipeline drugs in the Chronic Myeloid Leukemia (CML) pipeline landscape. It covers the chronic myeloid leukemia pipeline drug profiles, including clinical and nonclinical stage products, along with therapeutics assessment by product type, stage, route of administration, and molecule type, and further highlights inactive pipeline products in this space.<\/p>\n<p style=\"text-align: justify;\"><em>Explore the latest breakthroughs in the Chronic Myeloid Leukemia treatment landscape. Learn more about the evolving CML pipeline today @ <a rel=\"nofollow\" href=\"https:\/\/www.delveinsight.com\/sample-request\/chronic-myeloid-leukemia-pipeline-insight?utm_source=abnewswire&amp;utm_medium=pressrelease&amp;utm_campaign=xpr\">https:\/\/www.delveinsight.com\/sample-request\/chronic-myeloid-leukemia-pipeline-insight?utm_source=abnewswire&amp;utm_medium=pressrelease&amp;utm_campaign=xpr<\/a><\/em><\/p>\n<p style=\"text-align: justify;\"><strong>Key Takeaways from the Chronic Myeloid Leukemia Pipeline Report<\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li>\n<p>In March 2026, <strong>Top-line results from the Phase 3 ADVANCE-2 trial<\/strong> showed that pimavanserin did not achieve the primary endpoint of statistically significant improvement over placebo in the negative symptoms of schizophrenia.<\/p>\n<\/li>\n<li>\n<p>On January 08, 2026, M.D. Anderson Cancer Center initiated a <strong>Phase II clinical trial studying the effect of ASTX727 (decitabine and cedazuridine) in combination with dasatinib<\/strong> in treating patients with newly diagnosed Philadelphia chromosome-positive (Ph+) or BCR-ABL-positive Chronic Myeloid Leukemia in chronic phase.<\/p>\n<\/li>\n<li>\n<p>On January 06, 2026, <strong>Novartis Pharmaceuticals announced a study<\/strong> constituted of two stages: Treatment-Free Remission 1 (TFR1) and Treatment-Free Remission 2 (TFR2). The purpose of the TFR1 stage is to assess the effect of nilotinib reduced to half the standard dose for 12 months on treatment-free remission in patients with Chronic Myeloid Leukemia treated with first-line nilotinib who reached a sustained deep molecular response before entering the study.<\/p>\n<\/li>\n<li>\n<p>DelveInsight&rsquo;s Chronic Myeloid Leukemia Pipeline Insight report depicts a robust space with 20+ active players working to develop 20+ pipeline therapies for Chronic Myeloid Leukemia treatment.<\/p>\n<\/li>\n<li>\n<p>The leading Chronic Myeloid Leukemia companies include <strong>Kartos Therapeutics, AOP Orphan Pharmaceuticals, Biokine Therapeutics, Incyte Corporation, Sana Biotechnology, Novartis, Nerviano Medical Sciences, Sun Pharma Advanced Research Company and others.<\/strong><\/p>\n<\/li>\n<li>\n<p>Promising Chronic Myeloid Leukemia therapies include <strong>Imatinib mesylate, Dasatinib, Nilotinib, Decitabine (5-aza-2&rsquo;deoxycytidine\/ASTX727), Asciminib, Bosutinib, Peginterferon alfa-2a and others.<\/strong><\/p>\n<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><em>Download for updates and the latest revolution in chronic myeloid leukemia care @<a rel=\"nofollow\" href=\"https:\/\/www.delveinsight.com\/sample-request\/chronic-myeloid-leukemia-pipeline-insight?utm_source=abnewswire&amp;utm_medium=pressrelease&amp;utm_campaign=xpr\"> Chronic Myeloid Leukemia Clinical Trials Assessment<\/a><\/em><\/p>\n<p style=\"text-align: justify;\"><strong>Chronic Myeloid Leukemia Emerging Drugs Profile<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>Asciminib: Novartis<\/strong><\/p>\n<p style=\"text-align: justify;\">Asciminib is a first-in-class BCR-ABL1 inhibitor that works by a distinct mechanism from all currently approved tyrosine kinase inhibitors (TKIs). Rather than targeting the ATP-binding site of the BCR-ABL1 kinase, asciminib specifically targets the ABL myristoyl pocket (STAMP), locking the kinase in an inactive conformation. This allosteric mechanism confers activity against a broad spectrum of BCR-ABL1 mutations, including T315I, which is resistant to most approved TKIs. Asciminib is being evaluated in clinical trials for patients with CML in chronic phase, including those who have failed two or more prior TKI therapies.<\/p>\n<p style=\"text-align: justify;\"><strong>Dasatinib: Bristol-Myers Squibb \/ M.D. Anderson Cancer Center<\/strong><\/p>\n<p style=\"text-align: justify;\">Dasatinib is a second-generation BCR-ABL and Src family kinase inhibitor used to treat CML and Philadelphia chromosome-positive acute lymphoblastic leukemia. It inhibits BCR-ABL and several other kinases by binding to both the active and inactive conformations of the ABL kinase domain. Dasatinib is currently being evaluated in a Phase II clinical trial at M.D. Anderson Cancer Center in combination with ASTX727 (decitabine\/cedazuridine) in patients with newly diagnosed Ph+ or BCR-ABL-positive CML in chronic phase. The combination aims to leverage the hypomethylating activity of ASTX727 alongside dasatinib&rsquo;s kinase inhibition to improve outcomes and potentially facilitate deeper molecular responses.<\/p>\n<p style=\"text-align: justify;\"><em>For more information on the Chronic Myeloid Leukemia Emerging Drugs Profile, download DelveInsight&rsquo;s comprehensive<a rel=\"nofollow\" href=\"https:\/\/www.delveinsight.com\/sample-request\/chronic-myeloid-leukemia-pipeline-insight?utm_source=abnewswire&amp;utm_medium=pressrelease&amp;utm_campaign=xpr\"> Chronic Myeloid Leukemia Pipeline Insight<\/a> report.<\/em><\/p>\n<p style=\"text-align: justify;\"><strong>The Chronic Myeloid Leukemia Pipeline Report Provides<\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li>\n<p>Detailed insights about companies developing therapies for Chronic Myeloid Leukemia, with aggregate therapies developed by each company.<\/p>\n<\/li>\n<li>\n<p>Different therapeutic candidates, segmented into early-stage, mid-stage, and late-stage of development for Chronic Myeloid Leukemia treatment.<\/p>\n<\/li>\n<li>\n<p>Chronic Myeloid Leukemia companies that are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.<\/p>\n<\/li>\n<li>\n<p>Chronic Myeloid Leukemia drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.<\/p>\n<\/li>\n<li>\n<p>Detailed analysis of collaborations (company&ndash;company and company&ndash;academia), licensing agreements, and financing details for future advancement of the Chronic Myeloid Leukemia market.<\/p>\n<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><em>Learn more about Chronic Myeloid Leukemia drug opportunities in our comprehensive Chronic Myeloid Leukemia pipeline report @ <a rel=\"nofollow\" href=\"https:\/\/www.delveinsight.com\/sample-request\/chronic-myeloid-leukemia-pipeline-insight?utm_source=abnewswire&amp;utm_medium=pressrelease&amp;utm_campaign=xpr\">Chronic Myeloid Leukemia Unmet Needs<\/a><\/em><\/p>\n<p style=\"text-align: justify;\"><strong>Chronic Myeloid Leukemia Companies<\/strong><\/p>\n<p style=\"text-align: justify;\">There are 20+ key companies, such as Kartos Therapeutics, AOP Orphan Pharmaceuticals, Biokine Therapeutics, Incyte Corporation, Sana Biotechnology, Novartis, Nerviano Medical Sciences, Sun Pharma Advanced Research Company and others, developing therapies for Chronic Myeloid Leukemia, with Novartis having its CML drug candidate in the most advanced stage of clinical development.<\/p>\n<p style=\"text-align: justify;\"><strong>DelveInsight&rsquo;s Chronic Myeloid Leukemia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as:<\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li>\n<p>Intra-articular<\/p>\n<\/li>\n<li>\n<p>Intraocular<\/p>\n<\/li>\n<li>\n<p>Intrathecal<\/p>\n<\/li>\n<li>\n<p>Intravenous<\/p>\n<\/li>\n<li>\n<p>Ophthalmic<\/p>\n<\/li>\n<li>\n<p>Oral<\/p>\n<\/li>\n<li>\n<p>Parenteral<\/p>\n<\/li>\n<li>\n<p>Subcutaneous<\/p>\n<\/li>\n<li>\n<p>Topical<\/p>\n<\/li>\n<li>\n<p>Transdermal<\/p>\n<\/li>\n<li>\n<p>Molecule Type<\/p>\n<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong>Chronic Myeloid Leukemia products have been categorized under various Molecule types such as:<\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li>\n<p>Oligonucleotide<\/p>\n<\/li>\n<li>\n<p>Peptide<\/p>\n<\/li>\n<li>\n<p>Small molecule<\/p>\n<\/li>\n<li>\n<p>Product Type<\/p>\n<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><em>Discover the latest advancements in Chronic Myeloid Leukemia treatment @<a rel=\"nofollow\" href=\"https:\/\/www.delveinsight.com\/sample-request\/chronic-myeloid-leukemia-pipeline-insight?utm_source=abnewswire&amp;utm_medium=pressrelease&amp;utm_campaign=xpr\"> Chronic Myeloid Leukemia Market Drivers and Barriers, and Future Perspectives<\/a><\/em><\/p>\n<p style=\"text-align: justify;\"><strong>Scope of the Chronic Myeloid Leukemia Pipeline Report<\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li>\n<p>Coverage: Global<\/p>\n<\/li>\n<li>\n<p>Chronic Myeloid Leukemia Companies: Kartos Therapeutics, AOP Orphan Pharmaceuticals, Biokine Therapeutics, Incyte Corporation, Sana Biotechnology, Novartis, Nerviano Medical Sciences, Sun Pharma Advanced Research Company and others.<\/p>\n<\/li>\n<li>\n<p>Chronic Myeloid Leukemia Therapies: Imatinib mesylate, Dasatinib, Nilotinib, Decitabine (ASTX727), Asciminib, Bosutinib, Peginterferon alfa-2a and others.<\/p>\n<\/li>\n<li>\n<p>Chronic Myeloid Leukemia Therapeutic Assessment by Product Type: Mono, Combination, Mono\/Combination<\/p>\n<\/li>\n<li>\n<p>Chronic Myeloid Leukemia Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III<\/p>\n<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong>Table of Contents<\/strong><\/p>\n<p style=\"text-align: justify;\">1. Introduction<\/p>\n<p style=\"text-align: justify;\">2. Executive Summary<\/p>\n<p style=\"text-align: justify;\">3. Chronic Myeloid Leukemia: Overview<\/p>\n<p style=\"text-align: justify;\">4. Pipeline Therapeutics<\/p>\n<p style=\"text-align: justify;\">5. Therapeutic Assessment<\/p>\n<p style=\"text-align: justify;\">6. Chronic Myeloid Leukemia &ndash; DelveInsight&rsquo;s Analytical Perspective<\/p>\n<p style=\"text-align: justify;\">7. Late Stage Products (Phase III)<\/p>\n<p style=\"text-align: justify;\">8. Mid Stage Products (Phase II)<\/p>\n<p style=\"text-align: justify;\">9. Early Stage Products (Phase I)<\/p>\n<p style=\"text-align: justify;\">10. Preclinical and Discovery Stage Products<\/p>\n<p style=\"text-align: justify;\">11. Inactive Products<\/p>\n<p style=\"text-align: justify;\">12. Chronic Myeloid Leukemia Key Companies<\/p>\n<p style=\"text-align: justify;\">13. Chronic Myeloid Leukemia Key Products<\/p>\n<p style=\"text-align: justify;\">14. Chronic Myeloid Leukemia Unmet Needs<\/p>\n<p style=\"text-align: justify;\">15. Chronic Myeloid Leukemia Market Drivers and Barriers<\/p>\n<p style=\"text-align: justify;\">16. Chronic Myeloid Leukemia Future Perspectives and Conclusion<\/p>\n<p style=\"text-align: justify;\">17. Chronic Myeloid Leukemia Analyst Views<\/p>\n<p style=\"text-align: justify;\">18. Appendix<\/p>\n<p><span style='font-size:18px !important;'>Media Contact<\/span><br \/><strong>Company Name:<\/strong> <a href=\"https:\/\/www.abnewswire.com\/companyname\/delveinsight.com_75707.html\" rel=\"nofollow\">DelveInsight Business Research LLP<\/a><br \/><strong>Contact Person:<\/strong> Arpit Anand<br \/><strong>Email:<\/strong> <a href=\"https:\/\/www.abnewswire.com\/email_contact_us.php?pr=chronic-myeloid-leukemia-clinical-trial-pipeline-appears-robust-with-20-key-pharma-companies-actively-working-in-the-domain-delveinsight-kartos-therapeutics-aop-orphan-pharmaceuticals\" rel=\"nofollow\">Send Email<\/a><br \/><strong>Phone:<\/strong> +14699457679<br \/><strong>Address:<\/strong>304 S. Jones Blvd #2432  <br \/><strong>City:<\/strong> Las Vegas<br \/><strong>State:<\/strong> Nevada<br \/><strong>Country:<\/strong> United States<br \/><strong>Website:<\/strong> <a href=\"https:\/\/www.delveinsight.com\/consulting\/due-diligence-services\" target=\"_blank\" rel=\"nofollow\">https:\/\/www.delveinsight.com\/consulting\/due-diligence-services<\/a><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.abnewswire.com\/press_stat.php?pr=chronic-myeloid-leukemia-clinical-trial-pipeline-appears-robust-with-20-key-pharma-companies-actively-working-in-the-domain-delveinsight-kartos-therapeutics-aop-orphan-pharmaceuticals\" alt=\"\" width=\"1px\" height=\"1px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chronic Myeloid Leukaemia \u2013 Pipeline Insight, 2026 DelveInsight&#8217;s latest report provides comprehensive insights about 20+ companies, including Kartos Therapeutics, AOP Orphan Pharmaceuticals, Biokine Therapeutics, Incyte Corporation, Sana Biotechnology, Novartis, Nerviano Medical Sciences, Sun Pharma Advanced Research Company and others, developing &hellip; <a href=\"https:\/\/www.abnewswire.com\/pressreleases\/chronic-myeloid-leukemia-clinical-trial-pipeline-appears-robust-with-20-key-pharma-companies-actively-working-in-the-domain-delveinsight-kartos-therapeutics-aop-orphan-pharmaceuticals_795291.html\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[401,405,417,406,423],"tags":[],"class_list":["post-795291","post","type-post","status-publish","format-standard","hentry","category-Business","category-Health-Medicine","category-Marketing-Sales","category-Pharmaceuticals-Biotech","category-Professional-Services"],"_links":{"self":[{"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/posts\/795291","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/comments?post=795291"}],"version-history":[{"count":0,"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/posts\/795291\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/media?parent=795291"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/categories?post=795291"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/tags?post=795291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}