{"id":677760,"date":"2023-11-21T19:24:01","date_gmt":"2023-11-21T19:24:01","guid":{"rendered":"https:\/\/www.abnewswire.com\/pressreleases\/?p=677760"},"modified":"2023-11-21T19:24:01","modified_gmt":"2023-11-21T19:24:01","slug":"propulsion-of-alpha1-antitrypsin-deficiency-clinical-trial-pipeline-as-novel-and-extensive-12-therapies-likely-to-enter-in-the-domain-delveinsight","status":"publish","type":"post","link":"https:\/\/www.abnewswire.com\/pressreleases\/propulsion-of-alpha1-antitrypsin-deficiency-clinical-trial-pipeline-as-novel-and-extensive-12-therapies-likely-to-enter-in-the-domain-delveinsight_677760.html","title":{"rendered":"Propulsion of Alpha-1 Antitrypsin Deficiency Clinical Trial Pipeline as Novel and Extensive 12+ Therapies Likely to Enter in the Domain | DelveInsight"},"content":{"rendered":"<div style=\"float:right;  width:250px; padding:8px 10px 10px 10px;\"><a href=\"https:\/\/www.abnewswire.com\/uploads\/1700566889.jpeg\" style=\"border:none !important;\" target=\"_blank\" rel=\"nofollow\" ><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-29\" title=\"Propulsion of Alpha-1 Antitrypsin Deficiency Clinical Trial Pipeline as Novel and Extensive 12+ Therapies Likely to Enter in the Domain | DelveInsight\" src=\"https:\/\/www.abnewswire.com\/uploads\/1700566889.jpeg\" alt=\"Propulsion of Alpha-1 Antitrypsin Deficiency Clinical Trial Pipeline as Novel and Extensive 12+ Therapies Likely to Enter in the Domain | DelveInsight\" width=\"225\" height=\"225\" \/><\/a><\/div>\n<p style=\"text-align: justify;\">DelveInsight&rsquo;s, &ldquo;Alpha1-Antitrypsin Deficiency Pipeline Insight 2023&rdquo; report provides comprehensive insights about 12+ companies and 12+ pipeline drugs in the Alpha1-Antitrypsin Deficiency pipeline landscape. It covers the Alpha1-Antitrypsin Deficiency pipeline drug profiles, including Alpha1-Antitrypsin Deficiency clinical trials and nonclinical stage products. It also covers the Alpha1-Antitrypsin Deficiency therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.<\/p>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\"><strong>To explore more information on the latest breakthroughs in the Alpha-1 Antitrypsin Deficiency Pipeline treatment landscape of the report, click here @&nbsp;<a rel=\"nofollow\" href=\"https:\/\/www.delveinsight.com\/report-store\/alpha-1-antitrypsin-deficiency-aatd-pipeline-insight?utm_source=abnewswire&amp;utm_medium=pressrelease&amp;utm_campaign=ypr\" target=\"_blank\">Alpha-1 Antitrypsin Deficiency Pipeline Outlook&nbsp;Report<\/a><\/strong><\/p>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\"><strong>Key Takeaways from the Alpha-1 Antitrypsin Deficiency Pipeline Report<\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li>DelveInsight&rsquo;s Alpha-1 Antitrypsin Deficiency Pipeline report depicts a robust space with 12+ active players working to develop 12+ pipeline therapies for Alpha-1 Antitrypsin Deficiency.<\/li>\n<li>The leading Alpha-1 Antitrypsin Deficiency Companies include Octapharma, Dicerna Pharmaceuticals, Alnylam Pharmaceuticals, Arrowhead Pharmaceuticals, Vertex Pharmaceuticals, AstraZeneca, Kamada, Ltd, and Others.<\/li>\n<li>Promising Alpha-1 Antitrypsin Deficiency Pipeline Therapies include Fazirsiran Injection, Alpha-1 MP, ARO AAT, ALN-AAT02, and others<\/li>\n<li>In March 2023, Takeda initiated a randomized, double-blind, placebo-controlled, Phase III study to evaluate theefficacy and safety of Fazirsiran in the treatment of Alpha-1 Antitrypsin Deficiency-Associated liver disease with METAVIR StageF2 to F4 fibrosis. The main aim of this study is to learn if fazirsiran reduces liver scarring (fibrosis) compared to placebo. Otheraims are to learn if fazirsiran slows down the disease worsening in the liver, to get information on how fazirsiran affects thebody (called pharmacodynamics), to learn if fazirsiran reduces other liver injury (inflammation) and the abnormal Z-AAT proteinin the liver, to get information on how the body processes fazirsiran (called pharmacokinetics), to test how well fazirsiran workscompared with a placebo in improving measures of liver scarring including imaging and liver biomarkers (substances in theblood that the body normally makes and help show if liver function is improving, staying the same, or getting worse) as well asto check for side effects in participants treated with fazirsiran compared with those who received placebo. The trial is currentlyrecruiting participants and is expected to be completed by March 2027, with an estimated enrollment of 160 participants.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\"><strong>For further information, refer to the detailed Alpha-1 Antitrypsin Deficiency Unmet Needs, Alpha-1 Antitrypsin Deficiency Market Drivers, and Alpha-1 Antitrypsin Deficiency Market Barriers, click here for&nbsp;<a rel=\"nofollow\" href=\"https:\/\/www.delveinsight.com\/sample-request\/alpha-1-antitrypsin-deficiency-aatd-pipeline-insight?utm_source=abnewswire&amp;utm_medium=pressrelease&amp;utm_campaign=ypr\" target=\"_blank\">Alpha-1 Antitrypsin Deficiency Ongoing Clinical Trial Analysis<\/a><\/strong><\/p>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\"><strong>Alpha-1 Antitrypsin Deficiency Overview<\/strong><\/p>\n<p style=\"text-align: justify;\">Alpha-1-antitrypsin (AAT) is a protein produced in the liver that protects the body&#8217;s tissues from being damaged by infection-fighting agents released by its immune system. In alpha-1 antitrypsin deficiency, the body&rsquo;s normal production of AAT is reduced, resulting in the destruction of sensitive lung tissue. AAT deficiency is inherited.<\/p>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\"><strong>Alpha-1 Antitrypsin Deficiency Emerging Drugs Profile<\/strong><\/p>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<ul style=\"text-align: justify;\">\n<li><strong>ARO AAT: Arrowhead Pharmaceuticals<\/strong><\/li>\n<\/ul>\n<p style=\"text-align: justify;\">ARO AAT is a second generation, N-Acetylgalactosamine (GalNAc) based, subcutaneously administered RNA interference based therapeutic. ARO-AAT is designed to knock down the hepatic production of the mutant alpha-1 antitrypsin (Z-AAT) protein, the cause of progressive liver disease in AATD patients. In June 2019, the US FDA has granted Fast Track designation to ARO-AAT. ARO-AAT is in Phase III clinical studies for the treatment of liver disease associated with alpha-1 antitrypsin deficiency (AATD).<\/p>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<ul style=\"text-align: justify;\">\n<li><strong>ALN-AAT02: Alnylam Pharmaceuticals<\/strong><\/li>\n<\/ul>\n<p style=\"text-align: justify;\">ALN AAT02 is a subcutaneously administered RNAi therapeutic that targets alpha-1 antitrypsin (AAT). ALN-AAT02 is based on the Alnylam&#8217;s enhanced stabilization chemistry plus (ESC+)-GalNAc-conjugate technology, which enables subsequent subcutaneous dosing with increased selectivity and a wide therapeutic index. The drug is currently in Phase I\/II clinical development for the treatment of ZZ Type AAT Deficiency Liver Disease.<\/p>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\"><strong>Request a sample and discover the recent advances in Alpha-1 Antitrypsin Deficiency Ongoing Clinical Trial Analysis and Medications, click here @&nbsp;<a rel=\"nofollow\" href=\"https:\/\/www.delveinsight.com\/sample-request\/alpha-1-antitrypsin-deficiency-aatd-pipeline-insight?utm_source=abnewswire&amp;utm_medium=pressrelease&amp;utm_campaign=ypr\" target=\"_blank\">Alpha-1 Antitrypsin Deficiency Treatment Landscape<\/a><\/strong><\/p>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\"><strong>Alpha-1 Antitrypsin Deficiency Pipeline Therapeutics Assessment<\/strong><\/p>\n<p style=\"text-align: justify;\">There are approx. 12+ key companies which are developing the therapies for Alpha-1 Antitrypsin Deficiency. The companies which have their Alpha-1 Antitrypsin Deficiency drug candidates in the most advanced stage, i.e. phase III include, Deerland Probiotics &amp; Enzymes.<\/p>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\"><strong>Dive deep into rich insights for drugs for Alpha-1 Antitrypsin Deficiency Market Drivers and Alpha-1 Antitrypsin Deficiency Market Barriers, click here @&nbsp;<a rel=\"nofollow\" href=\"https:\/\/www.delveinsight.com\/sample-request\/alpha-1-antitrypsin-deficiency-aatd-pipeline-insight?utm_source=abnewswire&amp;utm_medium=pressrelease&amp;utm_campaign=ypr\" target=\"_blank\">Alpha-1 Antitrypsin Deficiency Unmet Needs and Analyst Views<\/a><\/strong><\/p>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\"><strong>Scope of the Alpha-1 Antitrypsin Deficiency Pipeline Report<\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li>Coverage- Global<\/li>\n<li>Alpha-1 Antitrypsin Deficiency Companies- <em>Octapharma, Dicerna Pharmaceuticals, Alnylam Pharmaceuticals, Arrowhead Pharmaceuticals, Vertex Pharmaceuticals, AstraZeneca, Kamada, Ltd<\/em>, and Others.<\/li>\n<li>Alpha-1 Antitrypsin Deficiency Pipeline Therapies- <em>Fazirsiran Injection, Alpha-1 MP, ARO AAT, ALN-AAT02<\/em>, and others<\/li>\n<li>Alpha-1 Antitrypsin Deficiency Pipeline Segmentation: Product Type, Molecule Type, Route of Administration<\/li>\n<\/ul>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\"><strong>Got Queries? Find out the related information on Alpha-1 Antitrypsin Deficiency Mergers and acquisitions, Licensing Activities @&nbsp;<a rel=\"nofollow\" href=\"https:\/\/www.delveinsight.com\/sample-request\/alpha-1-antitrypsin-deficiency-aatd-pipeline-insight?utm_source=abnewswire&amp;utm_medium=pressrelease&amp;utm_campaign=ypr\" target=\"_blank\">Alpha-1 Antitrypsin Deficiency Emerging Drugs, and Recent Trends<\/a><\/strong><\/p>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\"><strong>Table of Content<\/strong><\/p>\n<ol style=\"text-align: justify;\" start=\"1\">\n<li>Introduction<\/li>\n<li>Executive Summary<\/li>\n<li>Alpha-1 Antitrypsin Deficiency: Overview<\/li>\n<li>Pipeline Therapeutics<\/li>\n<li>Therapeutic Assessment<\/li>\n<li>Alpha-1 Antitrypsin Deficiency&ndash; DelveInsight&rsquo;s Analytical Perspective<\/li>\n<li>Late Stage Products (Phase III)<\/li>\n<li>ARO AAT: Arrowhead Pharmaceuticals<\/li>\n<li>Drug profiles in the detailed report&hellip;..<\/li>\n<li>Mid Stage Products (Phase II)<\/li>\n<li>Drug Name: Company Name<\/li>\n<li>Drug profiles in the detailed report&hellip;..<\/li>\n<li>Early Stage Products (Phase I\/II)<\/li>\n<li>ALN-AAT02: Alnylam Pharmaceuticals<\/li>\n<li>Drug profiles in the detailed report&hellip;..<\/li>\n<li>Preclinical and Discovery Stage Products<\/li>\n<li>Drug Name: Company Name<\/li>\n<li>Drug profiles in the detailed report&hellip;..<\/li>\n<li>Inactive Products<\/li>\n<li>Alpha-1 Antitrypsin Deficiency Key Companies<\/li>\n<li>Alpha-1 Antitrypsin Deficiency Key Products<\/li>\n<li>Alpha-1 Antitrypsin Deficiency- Unmet Needs<\/li>\n<li>Alpha-1 Antitrypsin Deficiency- Market Drivers and Barriers<\/li>\n<li>Alpha-1 Antitrypsin Deficiency- Future Perspectives and Conclusion<\/li>\n<li>Alpha-1 Antitrypsin Deficiency Analyst Views<\/li>\n<li>Alpha-1 Antitrypsin Deficiency Key Companies<\/li>\n<li>Appendix<\/li>\n<\/ol>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\"><strong>About Us<\/strong><\/p>\n<p style=\"text-align: justify;\">DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve.<\/p>\n<p><span style='font-size:18px !important;'>Media Contact<\/span><br \/><strong>Company Name:<\/strong> <a href=\"https:\/\/www.abnewswire.com\/companyname\/delveinsight.com_.html\" rel=\"nofollow\">DelveInsight Business Research LLP<\/a><br \/><strong>Contact Person:<\/strong> Yash Bhardwaj<br \/><strong>Email:<\/strong> <a href=\"https:\/\/www.abnewswire.com\/email_contact_us.php?pr=propulsion-of-alpha1-antitrypsin-deficiency-clinical-trial-pipeline-as-novel-and-extensive-12-therapies-likely-to-enter-in-the-domain-delveinsight\" rel=\"nofollow\">Send Email<\/a><br \/><strong>Phone:<\/strong> 9193216187<br \/><strong>Address:<\/strong>304  S. Jones Blvd #2432<br \/><strong>City:<\/strong> Las Vegas<br \/><strong>State:<\/strong> NV<br \/><strong>Country:<\/strong> United States<br \/><strong>Website:<\/strong> <a href=\"https:\/\/www.delveinsight.com\/report-store\/axillary-hyperhidrosis-ahh-market\" target=\"_blank\" rel=\"nofollow\">https:\/\/www.delveinsight.com\/report-store\/axillary-hyperhidrosis-ahh-market<\/a><\/p>\n<p><object type=\"text\/html\" data=\"https:\/\/www.delveinsight.com\/report-store\/axillary-hyperhidrosis-ahh-market\" style=\"width:900px; height:400px;\"><\/object><img decoding=\"async\" src=\"https:\/\/www.abnewswire.com\/press_stat.php?pr=propulsion-of-alpha1-antitrypsin-deficiency-clinical-trial-pipeline-as-novel-and-extensive-12-therapies-likely-to-enter-in-the-domain-delveinsight\" alt=\"\" width=\"1px\" height=\"1px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>DelveInsight&rsquo;s, &ldquo;Alpha1-Antitrypsin Deficiency Pipeline Insight 2023&rdquo; report provides comprehensive insights about 12+ companies and 12+ pipeline drugs in the Alpha1-Antitrypsin Deficiency pipeline landscape. It covers the Alpha1-Antitrypsin Deficiency pipeline drug profiles, including Alpha1-Antitrypsin Deficiency clinical trials and nonclinical stage products. &hellip; <a href=\"https:\/\/www.abnewswire.com\/pressreleases\/propulsion-of-alpha1-antitrypsin-deficiency-clinical-trial-pipeline-as-novel-and-extensive-12-therapies-likely-to-enter-in-the-domain-delveinsight_677760.html\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[405,406,413],"tags":[],"class_list":["post-677760","post","type-post","status-publish","format-standard","hentry","category-Health-Medicine","category-Pharmaceuticals-Biotech","category-Services"],"_links":{"self":[{"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/posts\/677760","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/comments?post=677760"}],"version-history":[{"count":0,"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/posts\/677760\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/media?parent=677760"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/categories?post=677760"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/tags?post=677760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}