{"id":346557,"date":"2019-03-25T08:55:03","date_gmt":"2019-03-25T08:55:03","guid":{"rendered":"http:\/\/www.abnewswire.com\/pressreleases\/?p=346557"},"modified":"2019-03-25T08:55:03","modified_gmt":"2019-03-25T08:55:03","slug":"university-of-maryland-medical-scientists-achieve-the-first-effective-chemotherapy-that-terminates-androgenindependent-advanced-prostate-cancer","status":"publish","type":"post","link":"https:\/\/www.abnewswire.com\/pressreleases\/university-of-maryland-medical-scientists-achieve-the-first-effective-chemotherapy-that-terminates-androgenindependent-advanced-prostate-cancer_346557.html","title":{"rendered":"University of Maryland Medical Scientists Achieve the First Effective Chemotherapy that Terminates \u201cAndrogen-Independent\u201d Advanced Prostate Cancer"},"content":{"rendered":"
Patients with “androgen-independent” prostate cancer have a life expectancy generally up to 5 years;and no available effective chemotherapy. University of Maryland Medical Center scientists, Dr. Leslie Costello and Dr. Renty Franklin, identified prolactin as the cause of the malignancy; and established the first chemotherapy that terminates the malignancy. This is the culmination of pioneering research in prostate cancer since 1975. Other patients have an effective available chemotherapy.\n <\/div>\n

University of Maryland Medical Scientists Achieve the First Effective Chemotherapy that Terminates “Androgen-Independent” Advanced Prostate Cancer.<\/p>\n

Dr. Leslie C. Costello, University of Maryland Medical Center scientist, was recently requested to participate as the consulting collaborator on a case of a patient with terminal “androgen-independent” prostate cancer. The patient was initially diagnosed with advanced prostate cancer, which included lymph node metastasis. The initiation and progression of the prostate malignancy is promoted primarily by testosterone; and is described as “androgen-dependent” malignancy. The patient received treatment with hormonal androgen ablation; along with chemotherapy and radiation therapy. The intent of this treatment was to attenuate the progressing malignancy; and extend the life of the patient. However, the treatment leads to the development of the untreatable terminal prostate cancer known as “androgen-independent” malignancy; and the patient had an expected survival of 2 years. The cause of this malignancy had been unknown, which has made it difficult to establish an effective chemotherapy.<\/p>\n

Dr. Costello and his colleague, Dr Renty B. Franklin, have been engaged in prostate research since 1975; which led to their recent discovery that the hormone, prolactin, initiates the development and progression of androgen-independent malignancy. That information provided the basis for their effective chemotherapy that suppresses the level of prolactin in the blood; and terminates the malignancy. After 8 weeks of their treatment, the patient’s plasma prolactin concentration decreased 88%, and he no longer exhibited prostate gland malignancy and metastasis. This is the first reported case of a patient who received a treatment that successfully terminated androgen-independent prostate cancer. <\/p>\n

Prostate cancer accounts for about 165,000 cases\/year with 25,000 deaths\/year in the U.S.; and 1.0 million cases\/year with 260,00 deaths\/year worldwide. Most of the deaths are due to advanced prostate cancer; which includes androgen-independent malignancy. Dr. Costello adds that it will be important to determine if their treatment will be effective in other patients with terminal androgen-independent malignancy. <\/p>\n

Dr. Costello and Dr. Franklin are Professors in the Department of Oncology and Diagnostic Sciences at the University of Maryland School of Dentistry; and in the University of Maryland Greenebaum Comprehensive Cancer Center. Dr. Costello and Dr. Franklin are included among the worldwide top 5% biomedical scientists.<\/p>\n

Article prepared on 03\/20\/2019 by:<\/p>\n

Leslie C. Costello, PhD.
lcostello@umaryland.edu<\/a>.<\/p>\n

Note: email responses will be accepted only from clinicians; and not from other individuals.<\/em><\/p>\n

Media Contact<\/span>
Company Name:<\/strong> University of Maryland School of Dentistry, Department of Oncology and Diagnostic Sciences; and the University of Maryland Comprehensive Cancer Center<\/a>
Contact Person:<\/strong> Leslie C. Costello
Email:<\/strong> Send Email<\/a>
Phone:<\/strong> 4107067618
City:<\/strong> Baltimore
State:<\/strong> MD
Country:<\/strong> United States
Website:<\/strong> https:\/\/www.umms.org\/ummc<\/a><\/p>\n

 <\/p>\n

\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

Patients with “androgen-independent” prostate cancer have a life expectancy generally up to 5 years;and no available effective chemotherapy. University of Maryland Medical Center scientists, Dr. Leslie Costello and Dr. Renty Franklin, identified prolactin as the cause of the malignancy; and … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[401],"tags":[],"class_list":["post-346557","post","type-post","status-publish","format-standard","hentry","category-Business"],"_links":{"self":[{"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/posts\/346557","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/comments?post=346557"}],"version-history":[{"count":0,"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/posts\/346557\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/media?parent=346557"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/categories?post=346557"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.abnewswire.com\/pressreleases\/wp-json\/wp\/v2\/tags?post=346557"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}