NEW YORK, USA – July 16, 2019 – With unparalleled modeling capabilities and high-quality deliveries, Creative Biolabs releases 6-OHDA and MPTP-induced PD models, which are two non-human primates models for parkinson’s disease.
Animal models not only play an indispensable role for studying pathogenesis, progression, and immune responses in diverse human diseases, but also constitute an essential part of preclinical evaluation/review of many therapeutic agents, vaccines, medical devices, etc. As the genetically closest species to human, non-human primates (NHPs) models generally are capable of producing more accurate and convincing data for pathogenesis characterization as well as preclinical research. In Creative Biolabs, various NHP models (e.g. rhesus macaque, cynomolgus monkey, marmosets, and green monkey) are kept in a clean, large and feed enriched environment to prevent stress and abnormal behaviors for the research of human brain functions and neurological diseases.
A neurological disease refers to any disorder within the nervous system, consisting of series of symptoms caused by structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves. Non-human primates (NHPs) models can greatly help develop dopamine agonists and deep brain stimulation which have proved to be available treatments of Parkinson’s disease.
Parkinson’s disease (PD) is a debilitating neurodegenerative disease with insidious onset and low progression, bringing plenty of inconveniences for patients due to physical symptoms of shaking, rigidity, slow movement, and walking difficulty while thinking and behavioral problems, and psychological symptoms of depression, constipation, and sleep disorders. For a better research of parkinson’s disease, Creative Biolabs now offers two neurological disease models, which are 6-OHDA and MPTP induced PD models.
6-OHDA provides a window of time to study oxidative stress and neurodegeneration and test neuroprotective strategies by inducing a retrograde, relatively progressive nigrostriatal lesion while MPTP is highly lipophilic and can cross the blood-brain barrier with the ability to replicate representative PD features such as rigidity, bradykinesia. Meanwhile, three major testing items are also provided to assist the research including general measures, behavioral tests, and functional imaging.
“Our monkey models of PD can present behavioral and neurochemical deficits that are characteristic of humans PD patients. In Creative Biolabs, comprehensive behavioral tests using a rating scale, fine motor skill tasks, and activity monitoring, etc. are designed by our professional scientists for an external measure of the brain”, introduced by the scientist in Creative Biolabs.
“Besides that, we also measure regular body weight and temperature records, standard blood and chemistry panels, frequency and characteristics of feces. Moreover, we provide in vivo functional imaging with positron emission tomography (PET) or magnetic resonance imaging (MRI) to assess neuronal connectivity.”
For the last decade, Creative Biolabs has devoted itself in establishing high-quality of Parkinson’s disease (PD) model, aiming to optimize and precisely control custom services. More information can be reached at https://www.creative-biolabs.com/drug-discovery/therapeutics.
Creative Biolabs is one of the few companies who can offer integrated drug discovery services for clients all over the world. Talented and well-trained scientists are working closely with each other to realize the goal of our customers. To discover and develop the qualified medicines of tomorrow, the scientists, who are concentrating on every important aspect of the industry, especially for the drug discovery pipeline, are able to undertake the entire discovery pipeline but also pleased to offer specific service based on clients’ requirements. Creative Biolabs offers comprehensive services ranging from target identification and validation, hit identification, hit to lead, lead optimization to the investigational new drug (IND).
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Address:45-1 Ramsey Road
State: New York
Country: United States