Pioneered by Arvinas, PROTAC is becoming a promising strategy to target the so called “undruggable” proteins such as estrogen-related receptor alpha, cellular retinoic acid binding proteins, and BRD4. Profacgen, as a leading biotech CRO, inspired by the discovery of PROTAC, now offers small molecule-based conjugation services to help its customers develop a new class of therapeutic agents targeting cancers and other difficult-to-treat diseases.
Profacgen, a leading biotech CRO, has been extensively working on bioconjugation services and assay development for more than a decade. This degradation-oriented method is generally more advantageous than traditional enzyme inhibitory strategy in that PROTAC can:
- Remove target proteins rather than blocking them;
- Avoid using high dosage to achieve sufficient inhibition;
- Reduce toxicity;
- Degrade “uninhibitable” proteins.
“Our services consist of different modules that cover every aspect of PROTAC development, from ligand identification to biological evaluation. We encourage our customers to choose individual modules that best fit their needs. To achieve the best efficacy, we do recommend our one-stop service package that delivers unrivaled value and will take care of our customers’ research project from scratch to full development.” said a representative from Profacgen.
To know more about Proteolysis Targeting Chimera service, please click https://www.profacgen.com/target-protein-degradation-proteolysis-targeting-chimera-protac.htm.
Profacgen provides process development and cGMP manufacturing services for biological active ingredients. We have ready access to state-of-the-art biopharmaceutical product development and manufacturing facilities and our staff scientists have demonstrable expertise in all aspects of biopharmaceutical manufacturing, from facility design and operation to the ability to provide best advice relating to product development. We also save our clients a great deal of time with bioprocess scale-up services. Our fermentation laboratories are equipped with state-of-the-art fermentors and bioreactors that enable us to express protein in large scale. Our customers can choose to enter into the protein purification pipeline at any stage depending on their needs.
Company Name: Profacgen
Contact Person: Ellen Burns
Email: Send Email
Address:45-1 Ramsey Road
State: New York
Country: United States