New York, Jul 30th, 2018 – Creative Proteomics announced the release of comprehensive peptidomics service, which is designed to efficiently identify and validate all endogenous peptides in a biological sample under investigation, also can be applied for specific biochemical processes. The peptidomics service offered by Creative Proteomics dramatically process peptide identification with high precision and repeatability.
At present, the applications of peptides mainly include comprehensive mapping of food protein digestion, characterization of protein processing-related protein hydrolysis, identification of peptide biomarkers for disease, and identification of hormones and other signaling molecules. Peptide biomarkers, as the ideal biomarker candidates, playing a pivotal role in biological systems. The two most commonly used peptide methods for biomarker discovery include pattern recognition and mono-/oligo- biomarker detection. While for peptide biomarker detection, there are many analytical techniques available, such as the popular UPLC and nanoLC which can be performed as the best analytical platform for high resolution, sensitivity, throughput and quantitation.
The quantification of small differences in peptide mass between samples is one of the most important and challenging tasks in peptide science. Both labeling (isotopes and isobaric) and label-free quantification can be applied for peptide science. For example, quantification of unlabeled peptides can be performed by extracting peptide signal intensities or by spectral counting. The quantification of MS is usually carried out with isotopically labeled samples, which advantage is that peptide fragmentation is not required for quantification.
Bottom-up proteomics employs proteolytic enzymes with high specificity, such as trypsin, which allow searching only for peptides that match those specific patterns. In peptide analysis, peptides are cleaved by a series of commonly unknown endogenous proteolytic enzymes, which require searching for all possible peptide fragments, greatly expanding the search space.
At the present stage, there are various problems need to be solved in peptide analysis which make the professional peptidomics service becoming increasingly popular in this industry. A variety of MS techniques have been widely applied in peptide service, such as ESI, MALDI and SELDI etc. Furthermore, Peptidomics has been successfully implemented with a variety of mass spectrometers, including track belts, quadrupole time-of-flight and micro TOF. With the development of MS/MS sequencing technology, MS-based peptide identification (that is Edman degradation) has mostly replaced traditional sequencing analysis. Many peptide related studies take mass spectrometry to examine a variety of tissue extracts.
About Creative Proteomics
Founded in 2005, Creative Proteomics provides customers with innovative proteomics identification and quantification services for biology related research to greatly enhance the performance of study and offering professional counseling of projects. Creative Proteomics is a well-recognized proteomics industry leader with more than 10 years experience and millions of customers worldwide.
Company Name: Creative Proteomics
Contact Person: Melissa George
Email: Send Email
Address:45-1 Ramsey Road
State: New York
Country: United States