Creative Biostructure Studies the Disease Process by Protein Crystallization Growth

The international space station is an ideal platform for protein crystallization growth. Some molecules can grow into purer crystal structure in the space. Quality advantages allow researchers to more easily find the target location, which contributes to the development of new drugs.

Creative Biostructure is a professional firm in the fields of biology, structural genomics and detection equipment. Their goal is to study the structure and function of the protein related to genetic information channel, designing transgenic macromolecules for DNA replication by gene synthesis and biological tools, and developing technologies combined with molecular biology, protein chemistry, X-ray crystallography and other sciences.

The international space station is an ideal platform for the growth of protein crystals. Improved space-grown protein crystals can provide three-dimensional X-ray structures for many high-value proteins, and ultimately these structures can help researchers identify specific protein functions and disease processes.

In space, the protein expression makes diverse phenotypes. Some phenotypes may even lead to some pathogen toxicity. Research in this area can help people better understand the pathogenesis, accelerating the design of new drugs and vaccine development. The body system will change, leading to bone loss, immune suppression, skeletal muscle mass and strength loss. These phenomena have occurred in a mouse model and astronauts. The analysis of these effects provides opportunities for the development and testing of drugs. In addition, these phenotypes can simulate the physiological changes of aging, and reveal the mechanism of senescence.

The study of the response from cells and tissues to stimuli (including drugs) is helpful to improve the tissue engineering and regenerative medicine in the space station. Some molecules can grow into purer crystal structures in the space. The quality advantages make it easier for researchers to find the target location, helping develop new drugs. For example, HQL-79 protein crystal grown in space. Its 3D protein structure is more detailed than that of the ground. The researchers also found a water molecule that had not been found previously. These discoveries contribute to the development of new therapies to inhibit Duchenne muscular dystrophy.

In addition, there are many successful cases in this field, such as the use of Salmonella to find the virulence gene that has not yet been found in the earth, providing a new potential target for vaccine development. Another one is the Denosumab developed for osteoporosis patients. It also carries out the experiments in the international space station, and provide evidence for the prevention of osteoporosis.

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Company Name: Creative Biostructure
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Address:45-1 Ramsey Road, Shirley, NY 11967, USA
City: Shirley
State: New York
Country: United States