With over a decade of working experience in antibody design and modification to fit various bio-conjugation strategies, especially for the development of antibody-drug conjugates (ADCs), Creative Biolabs recently upgraded their high-quality antibody design and conjugation service to better meet customized requirement of global clients.
As one major component of an antibody-drug conjugate (ADC), the antibody is the key for target specificity and serves as the cargo to deliver the cytotoxic drug (payload) that can be attached to different sites on an antibody using diverse conjugation chemistry. Multiple endogenous amino acids can serve as potential conjugation sites.
“In order to achieve more precisely controlled site-directed conjugations and subsequently a successful conjugation of DAR, special moieties with unique conjugation chemistries are engineered into antibody sequences in our antibody design services. ” a scientist from Creative Biolabs said that.
“Under mild and near-physiological conditions, endogenous amino acids such as Lys and Cys are chemically reactive as conjugation sites with antibody bioactivity. Our scientists are rich-experienced in performing Lysine conjugation (amine reaction) as well as Cysteine conjugation (thiol reactions) to create ADCs using these endogenous sites. We are also expertise in exploiting Tyrosine conjugation approaches as another innovated endogens site for ADC development.”
Scientists in Creative Biolabs keep in mind that designing a chemically compatible antibody for the conjugation chemistry is a key step that directly dictates the fate of an antibody conjugation project. With expertise and dedication, advanced antibody design platform and services from Creative Biolabs will be your best companion in creating customized ADCs.
About Creative Biolabs
Established in 2004, Creative Biolabs is highly specialized in advanced antibody biochemistry and engineering. With more than a decade of exploration and expansion, our current research and service capacity covers the entire new drug discovery and development pipeline, ranging from early discovery, preclinical evaluations, cGMP manufacturing, to clinical trials. As an international cooperation, we have established offices all around the globe with more than 200 well-trained full-time scientists and technicians, who work closely with our customers and research partners to develop new medicines for a better, healthier world.
Company Name: Creative Biolabs
Contact Person: Bella Smith
Email: Send Email
Address:45-1 Ramsey Road
State: New York
Country: United States