As an important class of highly potent biopharmaceutical drugs, antibody-drug conjugates or ADCs are designed as a targeted therapy for the treatment of people with cancer by targeting and killing only the cancer cells and sparing healthy cells. Three major components define an ADC—the monoclonal antibody, a cytotoxic payload, and a molecular linker that covalently bridges the other two components. A successful ADC should be chemically and physiologically stable in bloodstream, exert similar antigen binding pattern compared with the unconjugated antibody, and exhibit desired payload toxicological effects once internalized.
“Like traveling to a destination on a highway, our ADC development services extend from the starting point—antibody identification, to the final destination—creation and evaluation of the ADC, every step of the way. At the starting point of an ADC development project, we offer antibody screening services including the consultation in antigen selection, antigen-specific antibody screening, internalizing antibody selection, as well as proof-of-concept feasibility validation using Anti-Ab ADCs”, Said a scientist in Creative Biolabs.
“A suitable payload drug will be selected and coupled with a linker with desired releasing mechanism in ‘DrugLnk’ to assemble the ‘chemical warhead’ for an ADC, which is subsequently conjugated with the desired antibody using Antibody Design and Conjugation services. Certain modification or engineering of the selected antibody is also carried out in this service module.”
As a leader in the field of antibody-drug conjugate research and development, Creative Biolabs offers comprehensive one-stop-shop ADC engineering services to help create highly customized ADCs that are tailored to meet R&D timeline and budget of clients.
About Creative Biolabs
Established in 2004, Creative Biolabs is highly specialized in advanced antibody biochemistry and engineering. With more than a decade of exploration and expansion, our current research and service capacity covers the entire new drug discovery and development pipeline, ranging from early discovery, pre-clinical evaluations, cGMP manufacturing, to clinical trials. As an international cooperation, we have established offices all around the globe with more than 200 well-trained full-time scientists and technicians, who work closely with our customers and research partners to develop new medicines for a better, healthier world.
Company Name: Creative Biolabs
Contact Person: Bella Smith
Email: Send Email
Address:45-1 Ramsey Road
State: New York
Country: United States