New York, US, September 12, 2019 Creative Biolabs, an experienced expert in bispecific antibody field, releases a comprehensive list of BsAb engineering services for generation of Bispecific IgGs (BsIgGs), Appended IgGs, BsAb Fragments, Bispecific Fusion Proteins, BsAb Conjugates, to adjust the properties of BsAbs to meet each specific requirement of global clients in research and therapeutic market.
1 Bispecific IgGs Generation Service
Bispecific IgG is similar to a regular IgG with serum high stability, half-life and tissue penetration. In Creative Biolabs, scientists utilize recombinant expression or hybrid-hybridoma technology in terms of the actual condition and use mammalian cell lines as hosts to develop bispecific IgGs, including Fab Engineered-BsAbs, DT-lgG, Fab-arm exchange, Triomab, LUZ-Y, κλ-body, Orhogonal Fab Knob-into-holes (KIH), DuoBody, Azymetric, Charge pair, HA-TH, SEEDbody, differential protein A affinity, etc., are also available to avoid heavy chain-pairing problem of BsIgGs.
2 Appended IgGs Generation Service
Appended IgGs are based on molecules with additional antigen-binding moieties, which also is equipped with the Fc portion and the natural avidity to antigens. Depending on a prominent BsAb engineering platform, Creative Biolabs is capable of generating first-class Appended IgGs by genetic engineering, enabling the molecule design to be adapted to the desired activity, including IgG-scFv, IgG-v, Fv(H,L)-IgG, IgG(L,H)-Fv, KIH IgG-scFab, scFv4-Ig, Zybody.
3 Bispecific Antibody (BsAb) Fragments Generation Service
Bispecific antibody fragments are integrated by the Fv units with different linkers, characterized by small size and short serum half-life. Experts in Creative Biolabs can not only employ genetic engineering to generate BsAb fragments, but also use chemical conjugation with the help of homo-bifunctional crosslinkers to obtain the format of F(ab’)2, thereby providing BsAb fragment products targeting any pair of antigens of interest, including Bi-nanobody, Minibody, Tandem scFv, Diabody, scFv fragments, Triple Body, F(ab’)2, scFv-Fab fragments, Tetravalent HCAb, Intrabody.
4 Bispecific Fusion Proteins Generation Service
As a pre-targeting strategy for imaging and radioimmunotherapy, bispecific fusion proteins are generated in Creative Biolabs by linking other proteins to the antibody or antibody fragments for more functionality or specificity, in which recombinant expression is the dominant technology used, developing Dock and Lock, Bispecific TCRs, BsAb-HSA, BsAb-Toxin,etc.
5 Bispecific Antibody (BsAb) Conjugates
Creative Biolabs provides custom construction and production services of various bispecific antibody conjugates, mainly including Antibody-antibody (Ab-Ab), Antibody-peptide, Antibody-functionality. Scientists develop the full-length antibody or Fab of Ab-Ab bispecific antibody by the chemical programming approach. In addition, BsAb-functionality conjugates with the utilization of crosslinker can achieve more functionalities compared to conventional BsAbs.
The cutting-edge techniques and pioneering platform established by experts from Creative Biolabs can guarantee global clients BsAb products with not only high affinity and multiple valences to different targets, but also reliable safety for academic applications. More information can be reached at https://www.creative-biolabs.com/bsab.
About Creative Biolabs
Creative Biolabs was established in 2004 by scientists who are dedicated to conquering of cancer. Over the past 10 years, Creative Biolabs has grown into a recognized world leader in antibody (rAb) discovery, engineering, production, and analysis. Standing on the shoulder of a giant, the bispecific antibody (BsAb) team has a collective of experienced scientists committed to providing high-quality services to customers all over the world. Now, with the cutting-edge platforms and methods (quadroma development, chemical conjugation, and genetic engineering), a comprehensive list of bispecific antibody products is available to customers in academia and industry fields.
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Address:45-1 Ramsey Road
State: New York
Country: United States